ID   A0A109FJK0_9BASI        Unreviewed;      1222 AA.
AC   A0A109FJK0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=RHOSPDRAFT_32560 {ECO:0000313|EMBL:KWU45638.1};
OS   Rhodotorula sp. JG-1b.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX   NCBI_TaxID=1305733 {ECO:0000313|EMBL:KWU45638.1, ECO:0000313|Proteomes:UP000062823};
RN   [1] {ECO:0000313|EMBL:KWU45638.1, ECO:0000313|Proteomes:UP000062823}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JG-1b {ECO:0000313|EMBL:KWU45638.1,
RC   ECO:0000313|Proteomes:UP000062823};
RG   DOE Joint Genome Institute;
RA   Goordial J., Raymond-Bouchard I., Riley R., Ronholm J., Shapiro N.,
RA   Woyke T., Grigoriev I.V., Labutti K.M., Greer C., Whyte L., Bakermans C.;
RT   "Draft genome of eurypsychrophile Rhodotorula sp. JG1b isolated from
RT   permafrost in the hyper-arid Upper Elevation McMurdo Dry Valleys,
RT   Antarctica.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KQ954470; KWU45638.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A109FJK0; -.
DR   STRING; 1305733.A0A109FJK0; -.
DR   OrthoDB; 24699at2759; -.
DR   Proteomes; UP000062823; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   PANTHER; PTHR12673:SF270; DH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000062823}.
FT   DOMAIN          80..270
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          53..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..877
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          899..954
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1089..1123
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        616..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        749..763
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        824..838
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        906..920
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        931..945
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1222 AA;  133822 MW;  D368C7B8A9462812 CRC64;
     MFAPSSEAGG GPAVREVFCD VVVSDLELDA AGNCARPEGP IAAFVNSLGE IVTSGPSEPA
     RRPPSRPSTP GPAAQPDIEK VRRSLHELWV TEESYLRKIT SLLQDYAQPL RTFSKKRETA
     IIPAFEATHL FTNIEQLVPI SVAFERDLKD VAQRAQTERQ RVPEGFGEVI LAHVEQMAPY
     KKWLANVSAS ETIRRELDKH NSSFREFIER TQIHSRESAN STGGFKEFLA EPFQRVSRYR
     LMIDPIIQHL EPGDPNIEPL QIASTILSDI CSMEVDGGTQ RAAMFWSLKE TIDGFPDSLV
     DFERRLIATI DADEVIEVTD SRPTTLRCTL FLFQDKLLIA KRPSGDKQGK VHAGVDDLDR
     TVALYQTSHL SPSQASILGS PKKLRKGVLG FRGIVDVAAT AAIDLGERSS HHEFGLVFDH
     PPDNQSERWA GRPARRFVVA HTHASDTRLV EKRAWLEAFT EATLRLQLRA GALQARRGSI
     TFSGSLDAGR ARINWSLWDR QQYEQTRPDH KRKLALLLTS DGAARPLATP SRKRPFVSAT
     ATFLDPSRCR FEVCSTDSPG SDADIIENGR IAAAVASIAS SYGIDSFPAT KPLSPGSGRS
     RTRSNLLSVL DVFSSGGSSL KRGNSLISKS SSTATTTLDT PSLSGPSKRL QSAPLARRPL
     NKHSAPDLSR SVGASAATDA RDFGSREQLG RGDQAGFLHV GGSSRSRPRR SMSLPPPPSD
     LRSSPGPLAA FEDAPSPAEM TTGDFSEIDV DADMDHRQEE TPTARPQATE MPHTSPMAYR
     PQPISPHRRM MGPREMRGCE SADESPQRLP LARDGSPSPI RRGPRQESEF DKIQFEPADE
     PPRSGSSNAL SKRARPKVEP SPRPSPAKKM ASRLSTDAAL SADVRAAGRE LFAAPSRLAE
     ARPSQRIVSG ASTRTVRAIS PPRHSEQPDV FSPPRGSTTS EPAPSVTAAK FEEDEPMLDV
     TTRPFDQLRK HVDDMRLKLA RELANANKEN ERIVSPTALT RSPQTRNVFG KAIPENNVLD
     SPAARFSKAA SVFSDASDPR PRHKIDFTAL SEWTRRLADL IDTCEASVKA AEAGRDSPKE
     EGGSTKLEMA MLEQERDLIA AELAALKDEM TSLQQASRNT ELAFSATQEE NAKLRQAYMD
     ICGEADALHA DFNAALESVH LAAQAEPSAT GEYIELTAQL SQAVAARFDA EHQLRLYRRA
     VQAELEEKAR WAVLLRQHGL IA
//