ID   A0A109IJ65_9ACTN        Unreviewed;       837 AA.
AC   A0A109IJ65;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Polynucleotide kinase-phosphatase {ECO:0000313|EMBL:SCG71224.1};
GN   ORFNames=GA0070623_3576 {ECO:0000313|EMBL:SCG71224.1};
OS   Micromonospora rifamycinica.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=291594 {ECO:0000313|EMBL:SCG71224.1, ECO:0000313|Proteomes:UP000198226};
RN   [1] {ECO:0000313|EMBL:SCG71224.1, ECO:0000313|Proteomes:UP000198226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44983 {ECO:0000313|EMBL:SCG71224.1,
RC   ECO:0000313|Proteomes:UP000198226};
RA   Kjaerup R.B., Dalgaard T.S., Juul-Madsen H.R.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; LT607752; SCG71224.1; -; Genomic_DNA.
DR   RefSeq; WP_067309999.1; NZ_LT607752.1.
DR   AlphaFoldDB; A0A109IJ65; -.
DR   OrthoDB; 9807890at2; -.
DR   Proteomes; UP000198226; Chromosome i.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd07423; MPP_Prp_like; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041780; MPP_PrpE-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR024028; PNKP_bac.
DR   InterPro; IPR032380; PNKP_ligase_dom.
DR   NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR   PANTHER; PTHR42850:SF7; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE PRPE [ASYMMETRICAL]; 1.
DR   PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16542; PNKP_ligase; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Kinase {ECO:0000313|EMBL:SCG71224.1};
KW   Transferase {ECO:0000313|EMBL:SCG71224.1}.
FT   DOMAIN          182..377
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          463..832
FT                   /note="Polynucleotide kinase-phosphatase ligase"
FT                   /evidence="ECO:0000259|Pfam:PF16542"
SQ   SEQUENCE   837 AA;  90482 MW;  2343A257A2214FF1 CRC64;
     MTTLDIPELA LVALVGVSGS GKSTFAARHF APSQVLASDA FRAMVADDEN DQSASADAFA
     ALHHVAGVRL RRGRLTVVDA TNLQPHARAG LVRVAREHDV LPVAIVLDVP EALAWERTEA
     RADRTHGRQV LARMQRDLRR SYGHLEREGF RRVHVLRGVE EIDAARIRLE KLFNDRRELT
     GPFDIVGDVH GCRAELEELL ERLGFVLHRD DAGRPVDAAH PGGRTAVFVG DLVDRGPDSP
     GVLRLVMGMV AAGHAICVPG NHEHKLLRKL RGQDVKLTHG LAETMAQLDA EDPAFVTGVA
     SFIDGLVSHF VLDGGRLVVA HAGLKEAYHG RASGRVRSFA LWGETTGETD EYGLPVRYPW
     ARDYRGAATV VYGHTPTPVP EWVNNTICVD TGCVFGGKLT ALRYPERELV SVDARREWYA
     PARPLVSPPT RPDTVLDLAD VAGRRHLEHA YGTLTVPAEN AAAALEVMSR FAVDPGRLVW
     LPPTMAPCST STVAGFLEHP TQAFADYRAA GVERVVCQEK HMGSRAVVLV EREPGPFGGG
     VVHTRTGRPF FGPPLDGELL DRVRAAVGAA GLWDELGTDR LLLDCELLPW SAKADGLIRE
     QYAGVGAAGR AVLPAALDAL DAAAARGLPV DALRDRMTAR RAEIEAYSAA YRAYVAPVEG
     LRGVTLAPFA VLAGAKVTFT DRDHGWHLAL ADRLCAADPE FFTPTRRQVV ELSDASAVAA
     ATDWWSTLTA AGGEGMVVKP YAGPAARSAR GSLLQPGIKC RGREYLRIIY GPGYTDPAQL
     AALRRRSLGR KRGLALREHA LGLAALDGYV ADVPLWRRHA LVFAILACES EPVDPRL
//