ID A0A109LVX8_9SPHN Unreviewed; 496 AA.
AC A0A109LVX8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:KWV94666.1};
GN ORFNames=ASS64_08800 {ECO:0000313|EMBL:KWV94666.1};
OS Erythrobacter sp. AP23.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter.
OX NCBI_TaxID=499656 {ECO:0000313|EMBL:KWV94666.1, ECO:0000313|Proteomes:UP000058666};
RN [1] {ECO:0000313|EMBL:KWV94666.1, ECO:0000313|Proteomes:UP000058666}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP23 {ECO:0000313|EMBL:KWV94666.1,
RC ECO:0000313|Proteomes:UP000058666};
RA Lin W., Zheng Q.;
RT "Draft genome sequence of Erythrobacter sp. AP23.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWV94666.1}.
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DR EMBL; LNBY01000016; KWV94666.1; -; Genomic_DNA.
DR RefSeq; WP_067693502.1; NZ_LNBY01000016.1.
DR AlphaFoldDB; A0A109LVX8; -.
DR STRING; 499656.ASS64_08800; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000058666; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 187
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 334
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 343
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 496 AA; 55124 MW; 78BEE624F6A0D92F CRC64;
MSETQPPRVV VLGGGSAGWI TACLLHHRWH ARGGEVTVVE SPEIGIIGVG EGSTPQLKAL
FDHLGIEEAE WMAACDATYK LGIRFSGWSE REGHASYFHP FPGPVDLHTE PRFLHNCALR
RRGFDVPAHP DDWFLAEVLA EQRRTPHPQD SFPFAPSYGY HFDAHKLGAF LREWAIARGV
VHKSLKVTEV ELGSAGDVAA LLCEGGERID GDVFVDCSGF RSLIAQQKLG AKFLPFAENL
FNDRAVVMPT PHREAFKPQT DSIAMRAGWR WSIPLTTRVG NGYVYSSKYV SDEEAEAELR
QAIGMEHEGD VRVLQMRVGR VEDSWTRNCL AAGLAQGFIE PLEATALHIV IATALDFAEA
YEKGGFGPAH RDTFNRSIAA KYEGIRDYIV AHYRLNQRSD TQYWRDNATN HALSDNLKGL
MTAWFTHEDL REINLRQHDG NPHYANMSWH ALFAGYGTFP PQAKMVPLPA GLAGADRAKT
RAMLAACASN FADYKL
//
