ID   A0A109W7Z7_9FUSO        Unreviewed;       434 AA.
AC   A0A109W7Z7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Radical SAM protein {ECO:0000313|EMBL:AMD95881.1};
GN   ORFNames=AXF11_10045 {ECO:0000313|EMBL:AMD95881.1};
OS   Leptotrichia sp. oral taxon 847.
OC   Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Leptotrichiaceae;
OC   Leptotrichia.
OX   NCBI_TaxID=1785996 {ECO:0000313|EMBL:AMD95881.1, ECO:0000313|Proteomes:UP000065271};
RN   [1] {ECO:0000313|Proteomes:UP000065271}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0260 {ECO:0000313|Proteomes:UP000065271};
RA   Holder M.E., Ajami N.J., Petrosino J.F.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR   EMBL; CP014231; AMD95881.1; -; Genomic_DNA.
DR   RefSeq; WP_068157871.1; NZ_CP014231.1.
DR   AlphaFoldDB; A0A109W7Z7; -.
DR   KEGG; lot:AXF11_10045; -.
DR   OrthoDB; 9801424at2; -.
DR   Proteomes; UP000065271; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd02068; radical_SAM_B12_BD; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR   InterPro; IPR034466; Methyltransferase_Class_B.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR023404; rSAM_horseshoe.
DR   PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR   PANTHER; PTHR43409:SF12; BLL1977 PROTEIN; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR   SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR   SMART; SM00729; Elp3; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00022485};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT   DOMAIN          2..127
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
FT   DOMAIN          41..99
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000259|PROSITE:PS50206"
FT   DOMAIN          150..373
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   434 AA;  50715 MW;  996C4B299E46E9BC CRC64;
     MKIAFLRPNM GGKRSNDAIE PLAFAVLSGL TDKTRHELML FDDRIEDIPM DLEVDLVVIS
     TFTMTARRAY ELADNYRKRG VYVMIGGYHA SLMPDEVQEH ADTVCVGSGE ITWNEFLRDL
     ENGVPKKRYG CTKLPDINDV VYDRSIYKGK KYSFVVPVQF GRGCMHQCEF CTIGAVHKGD
     FQHRSIENVI NEVKEIFRTN KRAKIVYFVD DNIFANKKKA LQLFEELKKL KIKWACQGSI
     DIARDEKLIK LMSEAGCIEM LLGFENINIK NIKKMKKVAN YKFDYEKIID IYKKYRILVH
     ASYVIGYDYD DKNCFDEILE FSKKHKFFLA GFNPALPIPG TPFYERLKKE GRLLYERWWL
     DENFRYGKAC FEPYNMTIEE FEAGILKCKV EYNRHSSIWK RLFDGAANFK HALVFLAVNY
     INRKEVYNKK GIKL
//