ID A0A117I581_9MYCO Unreviewed; 947 AA.
AC A0A117I581;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Membrane protein mmpL4 {ECO:0000313|EMBL:GAS88130.1};
GN ORFNames=RMCB_2226 {ECO:0000313|EMBL:GAS88130.1};
OS Mycolicibacterium brisbanense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=146020 {ECO:0000313|EMBL:GAS88130.1, ECO:0000313|Proteomes:UP000069620};
RN [1] {ECO:0000313|EMBL:GAS88130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM15654 {ECO:0000313|EMBL:GAS88130.1};
RA Katahira K., Ogura Y., Gotoh Y., Hayashi T.;
RT "Draft Genome Sequences of Five Rapidly Growing Mycobacterium Species, M.
RT thermoresistibile, M. fortuitum subsp. acetamidolyticum, M. canariasense,
RT M. brisbanense, and M. novocastrense.";
RL Genome Announc. 4:e00322-16(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAS88130.1}.
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DR EMBL; BCSX01000021; GAS88130.1; -; Genomic_DNA.
DR RefSeq; WP_062828810.1; NZ_JACKTM010000057.1.
DR AlphaFoldDB; A0A117I581; -.
DR STRING; 146020.RMCB_2226; -.
DR Proteomes; UP000069620; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..844
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 856..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..379
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 668..934
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 947 AA; 103305 MW; 7CF65C2437F42B25 CRC64;
MSEHRAGRPL VAKTVRAFAV PIIVFWALLA VTTNTFVPQV ERVAEELAGP LVPHYAPSQV
AMLRIGEKFQ ESTSTSMTML VLEADHPLGA PEHQYYDDLV RRLKADTAHV QYVMDTWGKP
ITAAGAQSLD GKAAYVLLRL AGDIGQIQAN DSVQAVRNMI AHDTPPPGLK VYVSGAAPLA
ADTVNIANSS LNNITIVTIF LIIFMLLLVY RSITTMLVPL FGVLVLMLAA KGVIATLGHF
GYIELSSFAV NMVVSLTLGA GTDYGIFLTG RYHEARLAGE SREDAYYTAY RGVSHVIIGS
GLTIAGAAFC LSFARLNYFH TMGPAVAISM VLTVAGALTI GPALLSVGSL FGLFDPKRQA
GAKLYRRIGT SVVRWPKPIL VASVTLVALG AVFVPTYQVS FDDRTYQPAD APANQGFQAA
DRHFPKSKLF SEMLMIESDH DMRNSADFIS LDRAAKALIR LPGVAMVQSI TRPMGRALEH
ASLPYLFTTQ GSGNGQQLPF TRQMNSNTDQ QAQIMAHTIT VLRQTIDLTQ KLADELHNTV
VTMEDMEQVT EQMRDQVANL DDFMRPLRNY FYWEPHCFDI PACWAFRSLF DMLDSVDSLA
GDIKDAVGSL EVVDKLLPQM VSQLKIMADD MQGLQALIVN TYGPSNIQAD NTDQTFDDMI
NVGNDFDTSR SDDFFYIPRE AFDNEDIKTG MALMMSPDGK AARFIVTHEG NAMGPEGIEH
VEQFPDAIKI ALKETSLAGS KIYIGGSGSN NRDIQQYAKS DLLIAAIAAF VLIFLIMMVI
TRSLVAALVI PGTVAFSYAG AFGLSVLIWQ HLIGLHLHWL ILPLTFIILV AVGSDYNLLL
IARLKEEVHA GLNTGLIRAL GSTGGVVTSA GLVFAFTMLA MLSSDLRTIG QVGSTVCIGL
LLDTLIVRSF IVPCLVRLLG PWFWWPTLVR SRPLRSATPH YATAEAR
//
