ID A0A117MRK2_9ACTN Unreviewed; 1017 AA.
AC A0A117MRK2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:KUL31929.1};
GN ORFNames=ADL15_20685 {ECO:0000313|EMBL:KUL31929.1};
OS Actinoplanes awajinensis subsp. mycoplanecinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL31929.1, ECO:0000313|Proteomes:UP000053244};
RN [1] {ECO:0000313|EMBL:KUL31929.1, ECO:0000313|Proteomes:UP000053244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL31929.1,
RC ECO:0000313|Proteomes:UP000053244};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL31929.1}.
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DR EMBL; LLZH01000189; KUL31929.1; -; Genomic_DNA.
DR RefSeq; WP_067693568.1; NZ_LLZH01000189.1.
DR AlphaFoldDB; A0A117MRK2; -.
DR OrthoDB; 3304401at2; -.
DR Proteomes; UP000053244; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053244};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 30..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..490
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 609..746
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 755..1011
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1017 AA; 110152 MW; A9D8B2C7F964491F CRC64;
MTTRTARAGF GAWIVALVVL YYVFPDAHLY TWALLGYSSA AAILVGTRLH RPDRRLPWYL
TSAALAFFTT GDTWYNLILA VGRHPGFPGL ADVFYLLVYP LLTSAFLLFI RSRSGRGDNR
AALLDALVPT VGLGLLAWVY WIAPFTRAQD LSVLEKVVSI GYPLGDVLVL AMILRMLAAI
GTRPKALTSL AVAMVGLLVS DVFYGQSQLR SDWTLGGPVD LGWIVFYAMV GYTALQPSMR
QMTEPAERSR AVMGRHRLGW LTAAALIAPA VLCLEYVQGR PAEIARGGIV DAPIIAAAAA
VMFLLVLARV ADLALAQRQA GARERALREA GALLFTAATE DDVAEAIRRA VDRLMPPNQA
YHLELTRPVP GHADVSVQWR AAADLPEGVG AGGFPLVLFA TQPLPGGTRH GQMIVGAAED
VLHALRPALE TLGAQIAVVV ERISLTAEVN QRDSEAYFRT LIQSTADVIL ILDEQDAVRY
ASPSATKLFG AIIEAGTPLT ALITADGQDA LRDVLARLKR GNGDLNGVEL TAQGPGRRQM
LIECDLRNLR DDPTVAGLVI TMRDVTEQRR LEDDLTHQAF HDSLTGLANR VLFRNRLEQA
YMVAERDGAT LGVLFVDLDD FKEVNDTLGH AIGDQLLLAV ARRISSIIGA GSTAARMGGD
EFAILVEQSD SADAAEDVAA RIVTALNSPL EVPDGEGSTH LVSGAVSIGV ATNRDADGAT
ELLRHADLAL YLAKGMGKGD WQRYQSDLAS AMVQRLEMRT QLHEAIEDEQ FMLQYQPIVE
LADQRVTGVE ALVRWQHPTR GLLGPFHFVE AAEESGAIVG IGAWVLGEAL RQFATWKAAD
PDTTLRYVSV NVSPRQFRAA DFVEQVRAAL IKADARPEWL LLEITESLVL KDADKVVQDL
RALRAMGVRV AIDDFGTGYS SLSYLRQMPV DVLKLDKSFI DDILTSRQQH ALVDAIITLA
GNLDLAVVAE GIEEPGQMLA LDAMGCHYGQ GYHFAKPLWP ADIPAMTESA RPAAVSA
//
