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Database: UniProt
Entry: A0A117Q629_9ACTN
LinkDB: A0A117Q629_9ACTN
Original site: A0A117Q629_9ACTN 
ID   A0A117Q629_9ACTN        Unreviewed;       644 AA.
AC   A0A117Q629;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-SEP-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUN10349.1};
GN   ORFNames=AQI95_01060 {ECO:0000313|EMBL:KUN10349.1};
OS   Streptomyces yokosukanensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN10349.1, ECO:0000313|Proteomes:UP000053127};
RN   [1] {ECO:0000313|EMBL:KUN10349.1, ECO:0000313|Proteomes:UP000053127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN10349.1,
RC   ECO:0000313|Proteomes:UP000053127};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT   strain for the species Streptomyces yokosukanensis.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUN10349.1}.
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DR   EMBL; LMWN01000001; KUN10349.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUN10349; KUN10349; AQI95_01060.
DR   Proteomes; UP000053127; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053127};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      337    465       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      551    620       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     345    352       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   644 AA;  71578 MW;  A2FE90FA4C99C874 CRC64;
     MWPRVLEQLL GEGRGQGVEV KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPIV
     SETLSRECGR PIRIAITVDD SAGEPPAPAA PVQQSPKPRY EEPELPSAPY EGYGRHRAAD
     QPPAEQQSRG DQLPTGRADQ LPVVRPAYPS EYQRREPGAW PRPAQDEYGW QQPRLGFPER
     DPYASPSSQD AYGSGSDPYG SPSDYRQQGM DRPSYEQQRA EYDNPRSEYD NPRGDFDSGR
     PDYDSARSEY APSRTEYDQR DPVRRELPDQ PVSGGPAHRG GTGAPGPLAA KPAPASGPGE
     PTARLNPKYL FDTFVIGASN RFAHAAAVAV AEAPAKAYNP LFIYGESGLG KTHLLHAIGH
     YARSLYPGTR VRYVSSEEFT NEFINSIRDG KGDSFRKRYR EMDILLVDDI QFLADKESTQ
     EEFFHTFNTL HNANKQIVLS SDRPPKQLVT LEDRLRNRFE WGLITDVQPP ELETRIAILR
     KKAVQEQLNA PPEVLEFIAS RISRNIRELE GALIRVTAFA SLNRQPVDLG LTEIVLKDLI
     PGGEDSAPEI TATAIMGATA DYFGLTVEDL CGTSRGRALV TARQIAMYLC RELTDLSLPK
     IGAQFGGRDH TTVMHADRKI RALMAERRSI YNQVTELTNR IKNG
//
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