ID A0A117RYR8_9ACTN Unreviewed; 629 AA.
AC A0A117RYR8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Propionate--CoA ligase {ECO:0000313|EMBL:KUO16592.1};
DE EC=6.2.1.17 {ECO:0000313|EMBL:KUO16592.1};
GN Name=prpE {ECO:0000313|EMBL:KUO16592.1};
GN ORFNames=AQJ91_35520 {ECO:0000313|EMBL:KUO16592.1};
OS Streptomyces dysideae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=909626 {ECO:0000313|EMBL:KUO16592.1, ECO:0000313|Proteomes:UP000053260};
RN [1] {ECO:0000313|EMBL:KUO16592.1, ECO:0000313|Proteomes:UP000053260}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RV15 {ECO:0000313|EMBL:KUO16592.1,
RC ECO:0000313|Proteomes:UP000053260};
RA Ruckert C., Abdelmohsen U.R., Winkler A., Hentschel U., Kalinowski J.,
RA Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces sp. RV15, isolated from a marine
RT sponge.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUO16592.1}.
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DR EMBL; LMXB01000086; KUO16592.1; -; Genomic_DNA.
DR RefSeq; WP_067029857.1; NZ_KQ949104.1.
DR AlphaFoldDB; A0A117RYR8; -.
DR STRING; 909626.AQJ91_35520; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000053260; Unassembled WGS sequence.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:KUO16592.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053260}.
FT DOMAIN 4..58
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 66..445
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 510..588
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 629 AA; 67827 MW; 23FD63014CCB4D91 CRC64;
MGTYEDAFRT STEDPESFWL KAAEGIDWDV TPRRALDSSG APFYRWFPNG RLNVCFNALD
RHIEAGRGEQ PALVYDSPVT DTRRTYTYEQ LKNEVASFAG ALAQLGVGHG DRVVIYMPMV
PEAVVAMLAC ARIGAVHSVV FGGFAPRELA LRIDDAAPKV AVSASCGIEG KRVIAYKPLL
DRAIELAVHK PEKCVILQRP QEHAELGPDD LDWGDLVAAA PPADCVPVPA TDPLYILYTS
GTTGKPKGVV RDSGGYAVAL HWSMGAVYDV GPGETMFTGS DVGWVVGHSY IVYAPLLAGA
TTVLYEGKPV GTPDAGQFWR VAADYRVKTM FTAPTAFRAI RKEDPKGVLT AGYDLSHLRY
LFLAGERLDP ETYHWASALL GVPVIDHWWQ TETGWPIVAN PVGIEPAPLK PGSPTRPLPG
WDVRVLDASS DPVPTGVDGA IVVRLPLPPG ALPTLWKDDD RYVASYLSAY AGYYLTGDSG
HIDDDGYVFV MGRTDDVINV AGHRLSTGSM EEALAAHPDV AECAVIGVAD DLKGQIPRGF
VVLKAGSNRE PSEVEAELVQ LVRERIGAVA SLKDVTVVAA LPKTRSGKIL RKTMRGIADG
HDEPIPSTVD DPGVIETLRP VLRRPGHTL
//
