ID A0A118DM29_9BURK Unreviewed; 159 AA.
AC A0A118DM29;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Transcriptional repressor NrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN Name=nrdR {ECO:0000256|HAMAP-Rule:MF_00440};
GN ORFNames=BSIN_0607 {ECO:0000313|EMBL:SMG01391.1}, WS67_02090
GN {ECO:0000313|EMBL:KVE24353.1};
OS Burkholderia singularis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=1503053 {ECO:0000313|EMBL:KVE24353.1, ECO:0000313|Proteomes:UP000062788};
RN [1] {ECO:0000313|EMBL:KVE24353.1, ECO:0000313|Proteomes:UP000062788}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSV85 {ECO:0000313|EMBL:KVE24353.1,
RC ECO:0000313|Proteomes:UP000062788};
RA Sahl J., Keim P., Wagner D.;
RT "Expanding the genomic diversity of Burkholderia species for the
RT development of highly accurate diagnostics.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SMG01391.1, ECO:0000313|Proteomes:UP000198460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 28154 {ECO:0000313|EMBL:SMG01391.1};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negatively regulates transcription of bacterial
CC ribonucleotide reductase nrd genes and operons by binding to NrdR-
CC boxes. {ECO:0000256|HAMAP-Rule:MF_00440}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00440};
CC Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00440};
CC -!- SIMILARITY: Belongs to the NrdR family. {ECO:0000256|HAMAP-
CC Rule:MF_00440}.
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DR EMBL; LOWA01000055; KVE24353.1; -; Genomic_DNA.
DR EMBL; FXAN01000072; SMG01391.1; -; Genomic_DNA.
DR RefSeq; WP_059520038.1; NZ_LOWA01000055.1.
DR AlphaFoldDB; A0A118DM29; -.
DR OrthoDB; 9807461at2; -.
DR Proteomes; UP000062788; Unassembled WGS sequence.
DR Proteomes; UP000198460; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00440; NrdR; 1.
DR InterPro; IPR005144; ATP-cone_dom.
DR InterPro; IPR003796; RNR_NrdR-like.
DR NCBIfam; TIGR00244; transcriptional regulator NrdR; 1.
DR PANTHER; PTHR30455; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR PANTHER; PTHR30455:SF2; TRANSCRIPTIONAL REPRESSOR NRDR; 1.
DR Pfam; PF03477; ATP-cone; 1.
DR PROSITE; PS51161; ATP_CONE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Metal-binding {ECO:0000256|HAMAP-Rule:MF_00440};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Reference proteome {ECO:0000313|Proteomes:UP000062788};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00440};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00440};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00440}; Zinc {ECO:0000256|HAMAP-Rule:MF_00440};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP-
KW Rule:MF_00440}.
FT DOMAIN 49..139
FT /note="ATP-cone"
FT /evidence="ECO:0000259|PROSITE:PS51161"
FT ZN_FING 3..34
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00440"
SQ SEQUENCE 159 AA; 18366 MW; C7C90B27E50FCE8C CRC64;
MRCPFCRHDD TQVVDSRVSE DGAAIRRRRR CSACDKRFTT YERVELALPA VVKKDGSRTE
FDRRKIVASM QLALRKRPVA ADAIDAAVAR IEYQLLASGE REVRSERLGE LVMNELRALD
TIAYVRFASV YRRFEDVSEF ADVIEEFRRT APAKPPRKR
//
