ID A0A124BXX5_ASPNG Unreviewed; 1019 AA.
AC A0A124BXX5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ion channel {ECO:0000313|EMBL:GAQ43763.1};
GN ORFNames=ABL_06424 {ECO:0000313|EMBL:GAQ43763.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ43763.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SAT4 family.
CC {ECO:0000256|ARBA:ARBA00038359}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|RuleBase:RU003857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ43763.1}.
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DR EMBL; BCMY01000010; GAQ43763.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A124BXX5; -.
DR PaxDb; 5061-CADANGAP00007876; -.
DR VEuPathDB; FungiDB:An09g04840; -.
DR VEuPathDB; FungiDB:An18g03690; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1114925; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1161745; -.
DR VEuPathDB; FungiDB:ATCC64974_9250; -.
DR VEuPathDB; FungiDB:ATCC64974_9260; -.
DR VEuPathDB; FungiDB:M747DRAFT_287652; -.
DR VEuPathDB; FungiDB:M747DRAFT_291410; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005267; F:potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR049326; Rhodopsin_dom_fungi.
DR PANTHER; PTHR33048:SF108; MEMBRANE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02860)-RELATED; 1.
DR PANTHER; PTHR33048; PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245); 1.
DR Pfam; PF20684; Fung_rhodopsin; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 27..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 469..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..532
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 748..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..281
FT /note="Rhodopsin"
FT /evidence="ECO:0000259|Pfam:PF20684"
FT DOMAIN 560..631
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 732..801
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 288..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1019 AA; 113928 MW; 7692E4277BFA933A CRC64;
MLAELLGRDD TGTTDKHVDR SVQKWNLATQ ILCITTMTIF FALRCFTRLV IMDGFRREDW
TCLGAWFLGV CYSIIALIMG HFGGGVHYAD VPVSHRIPFE KTVYVTMVMY GPTAYLTKLS
LLWIIARVFS PYRKTVIFIY VFLGIMLAYY IPAVIVKIRI CDPIAKFWAP DTPGSCLDQT
SIILADAVVS VVSDMAILIL PLPLTVGLQL PLKKKLRVMV VLGAGGLACA SSIVRLILII
LTGQSQDGTL AFMRINMFGN AEITIGVICA CLPALSALIS RTHREYTSNK YSSHKNTQTS
QYELSKVKNS RPSRADRGKN QMTLTEVGSD QDILIPNAQE APRIETTVRG DSERQGTETM
GIMRTVDVST TVTSRPAEDD GPQDWWIAST AIPLIAATTA PLANLMSIVA LVMPWKSKLL
GGTASSGAPA QELISDPRWC IALNATSLAC GIAGNVFLLF NFTRTLRYII ALPASIILWC
LATSILIGIT VATNIYDGPI SPDQTYSQAY WSAVIAAALY FFLTVILMIN MLGYVLGHYP
QYFALTDGQR TLILQTTAFV VWLLIGAAIF HAVIDGISFA DALYFSDVTI LTLGYGDITP
PSSVGKGLVF PYAVMGIIIL GLVVGSIHDF ARELQYDNVV RKHVERKRQA TIEHSISLDP
GAEDPHLKFK SKRPPRPGGR RAINALALVG RPKLLVMREE KDRFNAMRAI QYETVLFRRW
YNLILSLIMF GIVWTCGAVV FWRLEQITYF QALYFGFCSL LTIGYGDITP TTNAARPFFI
VWSLLSVPTM TVLISEMSDT IVVAFKHATS VFADWTVLPQ SGKYRDFLRK FPILYTTLQH
REENRRVNEG FHVGLENEER GTRAEHQHSL DHPPTRSLEE LASEPDTASG TGSGSGSTLH
FAQQLAYAIQ RTTRDVVEGE RKRYTYEEWV EFTRLIRFTD PSPDDVEIQE DEYGILNWDW
IGKTSPMLAT ETEPEWVLNR LCESLIRYVD IQARQAGTTR EEDEPTLKKQ REIKFEDDQ
//
