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Database: UniProt
Entry: A0A124F0Y6_9ACTN
LinkDB: A0A124F0Y6_9ACTN
Original site: A0A124F0Y6_9ACTN 
ID   A0A124F0Y6_9ACTN        Unreviewed;       618 AA.
AC   A0A124F0Y6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUJ49904.1};
GN   ORFNames=ADL25_10615 {ECO:0000313|EMBL:KUJ49904.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ49904.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|EMBL:KUJ49904.1, ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|EMBL:KUJ49904.1,
RC   ECO:0000313|Proteomes:UP000054048};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUJ49904.1}.
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DR   EMBL; LMWH01000070; KUJ49904.1; -; Genomic_DNA.
DR   RefSeq; WP_059127415.1; NZ_LMWH01000070.1.
DR   EnsemblBacteria; KUJ49904; KUJ49904; ADL25_10615.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054048};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT   DOMAIN      311    439       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      525    594       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     319    326       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   618 AA;  68172 MW;  961B73E4EC013A54 CRC64;
     MADVPADLAA VWPRVLEQLL GEGHGPGVEA KDEHWIKRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPVV SETLSRECGR PIRIAITVDD SVGEPPPAPA QSRYEESELI TPQAGDPYEG
     QGGYEGYGRH RADDHRGGRS DRLPAGPGDQ LPGARPAYPS EYQRPEPGAW PRPPQDDYSW
     QQQRLGFPDR DPYATPAPDY HGQSLPRSPY EQQRQDYDGA RSDFEQQRSG RHERPERPSA
     DGHVHRGGPV GPGPATGAPG PLAAQPAPAA GPGEPTARLN PKYLFDTFVI GASNRFAHAA
     AVAVAEAPAK AYNPLFIYGE SGLGKTHLLH AIGHYARSLY PGTRVRYVSS EEFTNEFINS
     IRDGKADAFR KRYRDMDILL VDDIQFLAQK ESTQEEFFHT FNTLHNANKQ IVLSSDRPPK
     QLITLEDRLR NRFEWGLITD VQPPELETRI AILRKKAVQE QLNAPPEVLE FIASRISRNI
     RELEGALIRV TAFASLNRQP VDLGLTEIVL KDLIPGGEDT APEITATAIM AATADYFGLT
     VEDLCGTSRG RALVTARQIA MYLCRELTDL SLPKIGAQFG GRDHTTVMHA DRKIRALMAE
     RRSIYNQVTE LTNRIKNG
//
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