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Database: UniProt
Entry: A0A124G584_9EURY
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ID   A0A124G584_9EURY        Unreviewed;       568 AA.
AC   A0A124G584;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=XE11_1766 {ECO:0000313|EMBL:KUL02431.1};
OS   Methanomicrobiales archaeon 53_19.
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanomicrobiales.
OX   NCBI_TaxID=1641394 {ECO:0000313|EMBL:KUL02431.1, ECO:0000313|Proteomes:UP000054757};
RN   [1] {ECO:0000313|EMBL:KUL02431.1, ECO:0000313|Proteomes:UP000054757}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=53_19 {ECO:0000313|EMBL:KUL02431.1};
RA   Hu P., Tom L., Singh A., Thomas B.C., Baker B.J., Piceno Y.M.,
RA   Andersen G.L., Banfield J.F.;
RT   "Genome-resolved metagenomic analysis reveals roles for candidate
RT   phyla and other microbial community members in biogeochemical
RT   transformations in oil reservoirs.";
RL   MBio 7:e01669-15(2015).
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUL02431.1}.
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DR   EMBL; LGHF01000044; KUL02431.1; -; Genomic_DNA.
DR   PATRIC; fig|1641394.3.peg.2661; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000054757; Unassembled WGS sequence.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000054757};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000054757};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        8    278       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      326    459       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       157    157       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     267    267       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     281    281       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   568 AA;  62902 MW;  E94C7AFB1F5D6BEE CRC64;
     MAKIERAQKL FLKALKEKFP GQDVESQKAK FYAFDGLNQS PRKKEFMAEN AKIVKERGID
     MYDPTRCHLG GIPMGQRQLM TYEVSGTGTF VEGDDLHFVN NAAMQQFWDD IRRTVIVNMD
     LAHQTLQKRL GKEVTPETIN EYLHVVNHAM PGAAVVQEHM VETHPALTDD CYVKVFTGDS
     ELADDIEPQF LLNVEKLFPK KQAEALINAV GKSMWQCVHI PTTVSRTCDG GTTSRWSAMQ
     IGMSFIGAYR MCAGEAAVAD LSYAAKHAGV IQMASHLPAR RARGPNEPGG IMFGNFADMI
     QTDRKYPNDP AKAALEVVGA GTMLFDQIWL GSYMSGGVGF TQYATAAYTD NILDEFTYYG
     MDYIKDKYKV DWQNPSPNDK VKPTQEIVND IATEVNLNGM EQYEQYPTMM EDHFGGSQRA
     GVLAAACGLS TAIATGNSNA GLNGWYLSML MHKEGWSRLG FFGYDLQDQC GSANTLSVRP
     DEGCIGEFRG PNYPNYAMNV GHQGEYAAIV GSSHFGRGDA WTLSPLIKIC FADPALKFDF
     AEPRKEFARG AIREFMPAGE RSLIIPAK
//
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