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Database: UniProt
Entry: A0A124I2W7_9ACTN
LinkDB: A0A124I2W7_9ACTN
Original site: A0A124I2W7_9ACTN 
ID   A0A124I2W7_9ACTN        Unreviewed;       638 AA.
AC   A0A124I2W7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUN81811.1};
GN   ORFNames=AQJ64_21710 {ECO:0000313|EMBL:KUN81811.1};
OS   Streptomyces griseoruber.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN81811.1, ECO:0000313|Proteomes:UP000052982};
RN   [1] {ECO:0000313|EMBL:KUN81811.1, ECO:0000313|Proteomes:UP000052982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN81811.1,
RC   ECO:0000313|Proteomes:UP000052982};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces griseoruber DSM 40281, type
RT   strain for the species Streptomyces griseoruber.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUN81811.1}.
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DR   EMBL; LMWW01000034; KUN81811.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUN81811; KUN81811; AQJ64_21710.
DR   Proteomes; UP000052982; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000052982};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895}.
FT   DOMAIN      331    459       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      545    614       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     339    346       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   638 AA;  70764 MW;  F55434D00F87AD19 CRC64;
     MWPRVLEQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPIV
     SETLSRECGR PIRIAITVDD SVGEPPAPPA PPVQQPKPRY EEPELPSGPY DSPYDEPKGR
     YDSTYDNSYD SPYDGSYGRH RAEQHPGPSG EGPRGEQLPT ARPAYPSEYQ RPEPGAWPLP
     QQDDYGWQQQ RLGFPERDPY ASPSQDPYGS PSPAPYSQDS YGQPPQDYRP QSMERPPYDA
     APYEPKRPEY DQRDAGRREL PEPPAGSGPP QRPGAPGVPG APAAPSPSAG GPGEPTARLN
     PKYLFDTFVI GASNRFAHAA AVAVAEAPAK AYNPLFIYGE SGLGKTHLLH AIGHYARSLY
     PGTRVRYVSS EEFTNEFINS IRDGKGDSFR KRYREMDILL VDDIQFLADK ESTQEEFFHT
     FNTLHNANKQ IVLSSDRPPK QLVTLEDRLR NRFEWGLITD VQPPELETRI AILRKKAVQE
     QLNAPPEVLE FIASRISRNI RELEGALIRV TAFASLNRQP VDLGLTEIVL KDLIPGGEDS
     APEITSTAIM SATADYFGLT VEDLCGTSRG RALVTARQIA MYLCRELTDL SLPKIGALFG
     GRDHTTVMHA DRKIRNLMAE RRSIYNQVTE LTNRIKAG
//
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