GenomeNet

Database: UniProt
Entry: A0A124I521_9ACTN
LinkDB: A0A124I521_9ACTN
Original site: A0A124I521_9ACTN 
ID   A0A124I521_9ACTN        Unreviewed;       682 AA.
AC   A0A124I521;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE            EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN   ORFNames=AQJ64_02805 {ECO:0000313|EMBL:KUN88619.1};
OS   Streptomyces griseoruber.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN88619.1, ECO:0000313|Proteomes:UP000052982};
RN   [1] {ECO:0000313|EMBL:KUN88619.1, ECO:0000313|Proteomes:UP000052982}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN88619.1,
RC   ECO:0000313|Proteomes:UP000052982};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces griseoruber DSM 40281, type strain
RT   for the species Streptomyces griseoruber.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC       {ECO:0000256|ARBA:ARBA00011870}.
CC   -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC       {ECO:0000256|ARBA:ARBA00008465}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN88619.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LMWW01000003; KUN88619.1; -; Genomic_DNA.
DR   RefSeq; WP_055637318.1; NZ_LIQS01000484.1.
DR   AlphaFoldDB; A0A124I521; -.
DR   STRING; 1943.AQJ64_02805; -.
DR   OrthoDB; 9762378at2; -.
DR   Proteomes; UP000052982; Unassembled WGS sequence.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR   CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR   InterPro; IPR006159; Acid_CoA_mut_C.
DR   InterPro; IPR016176; Cbl-dep_enz_cat.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR   InterPro; IPR006098; MMCoA_mutase_a_cat.
DR   NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR   NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR   PANTHER; PTHR48101:SF3; COENZYME B12-DEPENDENT MUTASE; 1.
DR   PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF01642; MM_CoA_mutase; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
PE   3: Inferred from homology;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00022628};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235}.
FT   DOMAIN          543..672
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
SQ   SEQUENCE   682 AA;  74735 MW;  80CA7E908D1A5E48 CRC64;
     MTERQPAEGT REKDRPWLMR TYAGHSTAEA SNELYRRNLA KGQTGLSVAF DLPTQTGYDS
     DHVLARGEVG RVGVPVAHLG DMRRLFQDIP LEQMNTSMTI NATAMWLLAL YQVVAEEQGA
     DITRLQGTTQ NDIVKEYLSR GTHVFPPGPS LRLTTDMIAY TVSHIPKWNP INICSYHLQE
     AGATPVQEIA YAMSTAIAVL DAVRDSGQVP AEKFGDVVAR ISFFVNAGVR FVEEMCKMRA
     FGRIWDQVTR ERYGIENPKQ RRFRYGVQVN SLGLTEAQPE NNVQRIVLEM LAVTLSKDAR
     ARAVQLPAWN EALGLPRPWD QQWSLRIQQV LAHESDLLEY EDLFEGSHVV EAKVARLVEE
     SLAEIGRIQE MGGAMAAVES GYLKSQLVSS HAERRARIES GQEKIVGVNI FETTEPNPLT
     ADLDTAIQTV DPAVEARVVA SLQHWRDTRY QPPFNHPRPC KALERLKEAA KGTDNLMEAT
     LECARAGVTT GEWAGALREV FGEFRAPTGV SSAPVAVPAE EGSAMSEVRR RVETTAKDLG
     TGKLRFLVGK PGLDGHSNGA EQIAVRARDA GFEVVYQGIR LTPEQIVDAA LAEDVHAVGL
     SILSGSHAQL VPDVLQRLRV AGATDIPVIA GGIIPNGDAE QLRAAGVAAV FTPKDFDITG
     IIGRIVDEIR KANKLDPLEV PA
//
DBGET integrated database retrieval system