ID A0A124I5E7_9ACTN Unreviewed; 601 AA.
AC A0A124I5E7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KUN89699.1};
GN ORFNames=AQJ66_03600 {ECO:0000313|EMBL:KUN89699.1};
OS Streptomyces bungoensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=285568 {ECO:0000313|EMBL:KUN89699.1, ECO:0000313|Proteomes:UP000053024};
RN [1] {ECO:0000313|EMBL:KUN89699.1, ECO:0000313|Proteomes:UP000053024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41781 {ECO:0000313|EMBL:KUN89699.1,
RC ECO:0000313|Proteomes:UP000053024};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces bungoensis DSM 41781, type strain
RT for the species Streptomyces bungoensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN89699.1}.
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DR EMBL; LMWX01000004; KUN89699.1; -; Genomic_DNA.
DR RefSeq; WP_061916164.1; NZ_KQ948851.1.
DR AlphaFoldDB; A0A124I5E7; -.
DR STRING; 285568.AQJ66_03600; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000053024; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053024}.
FT DOMAIN 15..193
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..292
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 322..499
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 502..598
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 601 AA; 63295 MW; 7D30818DD930954A CRC64;
MATPLSDPSL SPLKTIAVVG LGTMGTGITE VLAKAGREVI GIDVSEAQAA KSLAALESAT
ARAVERGRLT EQERAGVLAR VRTSTDLAAA ADADLVIEVA PESYEIKHQI FRELDGIVRP
ETILATGTNA LSVTRLAADS ARPERVLGLH FFNPAPAMRL VEVVSSVLTA PQAVATVTDL
AIELGKEPVA VGDRPGFVAD GLLFGYLNQA AAMYEARYAS REDIDAAMRL GCGLPMGPLA
LLDLIGIDTA RTVLEAMYAE SRDRLHAPAP ILKQLSEAGL TGRKSGRGFY TYEAPGSATV
VPDALTPASA GTGTAGRPVR SVGVAGSGTM ASGIAEVFAK AGYEVVLAAR GEEKAQAARA
RIGKSLARSV DKGRMTAEAA AQTLERITPV GSYDAFADVD LAVEAIAEDL EVKRQLFQAL
DKVCKPGAVL ATTTSSLPVV ACARATSRPQ DVIGMHFFNP APAMKLVEVV RTVLTADDVH
ATVREVCARI RKHAVDCGDR AGFIVNALLF PYLNNAIKMI EEHYASLDDI DAAMKLGGGY
PMGPFELLDV VGLDVSLAIE KVLHREFRDP GLAPAPLLEH LVAAGCLGRK TGRGFREYAR
R
//
