ID A0A125YNU4_TOXGV Unreviewed; 525 AA.
AC A0A125YNU4; A0A0F7V9L8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Translation initiation factor eIF2B subunit gamma {ECO:0000256|ARBA:ARBA00044196};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit gamma {ECO:0000256|ARBA:ARBA00044229};
GN ORFNames=BN1205_038040 {ECO:0000313|EMBL:CEL77939.1}, TGVEG_216260
GN {ECO:0000313|EMBL:ESS28722.1};
OS Toxoplasma gondii (strain ATCC 50861 / VEG).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=432359 {ECO:0000313|EMBL:ESS28722.1, ECO:0000313|Proteomes:UP000002226};
RN [1] {ECO:0000313|EMBL:ESS28722.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS28722.1};
RA Paulsen I.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50861 / VEG {ECO:0000313|Proteomes:UP000002226};
RA Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.;
RT "Annotation of Toxoplasma gondii VEG.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ESS28722.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:ESS28722.1};
RA Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA Roos D., Caler E., Lorenzi H.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEL77939.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VEG {ECO:0000313|EMBL:CEL77939.1};
RX PubMed=25875305; DOI=10.1371/journal.pone.0124473;
RA Ramaprasad A., Mourier T., Naeem R., Malas T.B., Moussa E., Panigrahi A.,
RA Vermont S.J., Otto T.D., Wastling J., Pain A.;
RT "Comprehensive Evaluation of Toxoplasma gondii VEG and Neospora caninum LIV
RT Genomes with Tachyzoite Stage Transcriptome and Proteome Defines Novel
RT Transcript Features.";
RL PLoS ONE 10:e0124473-e0124473(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
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DR EMBL; LN714501; CEL77939.1; -; Genomic_DNA.
DR EMBL; AAYL02000332; ESS28722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A125YNU4; -.
DR STRING; 432359.A0A125YNU4; -.
DR PaxDb; 5811-TGME49_016260; -.
DR EnsemblProtists; ESS28722; ESS28722; TGVEG_216260.
DR VEuPathDB; ToxoDB:TGVEG_216260; -.
DR eggNOG; KOG1462; Eukaryota.
DR OMA; NCVINPK; -.
DR Proteomes; UP000002226; Partially assembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR025877; MobA-like_NTP_Trfase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR45989; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1.
DR PANTHER; PTHR45989:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1.
DR Pfam; PF12804; NTP_transf_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:ESS28722.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002226}.
FT DOMAIN 30..97
FT /note="MobA-like NTP transferase"
FT /evidence="ECO:0000259|Pfam:PF12804"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58016 MW; 9A453CE21EC8672B CRC64;
MAPSAATSAP QTPAGSTEAR RTNPFLEFQV VVLAGGSSSR LSSLTGTPKE KGGCCKAMLP
VGNRPMLWYC LKNLQESRFG DAIVLTRQEE QAEILAYLRQ EFPNAFQRLE VVGLGREAET
GKSRGDFEED DVVCGTAEAL LQIKHLLVTD FFVITCDVIG PVDFFSLANL HRVENAACSV
YLLRRDYLSE GASEILDRGA HGKAGKGGKK KATPEKVDKD ANKGNPVAIA FEETETLLLG
IQDRHSISHG AQLAIPKLTL FYHPSVFVKA NLYDPHVYLF KLSALKILED PKLRNTLTSI
RFDLVPYMSL MQMTPQASLW SSSRLDCDVF DELLDSFDEP HKKREDKEQD RSREQGYTLA
NRPEQPRKGN KVVFALHPDC AGICCRVNNI HDYYEMNMKF CSNRMDELRG IMPEWMLPAQ
PAKKSPTMRD STVAEGCTFA ESAVIKRSIF GAEVSVGSKA RVTASVLLEG GKIEEEATIQ
RCIVGRRATV GKGCKLTNCQ VRHGYSVPPG TVAEDEVLPL FTDDA
//
