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Entry: A0A126R0Q7_9EURY
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ID   A0A126R0Q7_9EURY        Unreviewed;       558 AA.
AC   A0A126R0Q7;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   25-OCT-2017, entry version 11.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=YLM1_1111 {ECO:0000313|EMBL:AMK15668.1};
OS   Methanobrevibacter olleyae.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=294671 {ECO:0000313|EMBL:AMK15668.1, ECO:0000313|Proteomes:UP000066376};
RN   [1] {ECO:0000313|Proteomes:UP000066376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YLM1 {ECO:0000313|Proteomes:UP000066376};
RG   New Zealand Agricultural Greenhouse Gas Research Centre/Pastoral Greenhouse Gas Research Consortium;
RA   Kelly W.J., Li D., Lambie S.C., Attwood G.T., Altermann E.,
RA   Leahy S.C.;
RT   "The draft genome sequence of the rumen methanogen Methanobrevibacter
RT   olleyae YLM1.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP014265; AMK15668.1; -; Genomic_DNA.
DR   RefSeq; WP_067147089.1; NZ_CP014265.1.
DR   EnsemblBacteria; AMK15668; AMK15668; YLM1_1111.
DR   GeneID; 28489414; -.
DR   KEGG; mol:YLM1_1111; -.
DR   PATRIC; fig|294671.3.peg.1162; -.
DR   KO; K00399; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000066376; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000066376};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN       10    276       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      323    447       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       155    155       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     265    265       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     279    279       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   558 AA;  61565 MW;  F643CBB8E744EAEC CRC64;
     MTKGEKLENK RFLEALTQKF KGEDQEDQQT SFYCFDGWKQ SPRKREFFDA ANELAKKRDN
     LPFYNPDIGV PLGQRQLMSY KISGTEDYVE GDDLHFCNNA AIQQLVDDIK RTVIVGMDTA
     HSVLQERLGV EVTPETINEY METINHALPG GAVVQEHMVE VHPGLASDCY AKIFTGNDEL
     ADELDKRVLI DINKEFPEEQ AEMLKEYIGN KTYQVSRVPT LVVRACDGGT VSRWSAMQIG
     MSFITAYSLC AGEAAIADFS YAAKHADVIG MAAILPARRA RGANEPGGVP FGIFADMIQT
     SRISDDPAKI TLEVIGGAAT FYDQVWLGSY MSGGVGFTQY ASATYTDDIL DDFIYYGKDY
     VEKNYGMCQA EANFDNVKDI ATEVTIYGLE QYEIPTLLED HFGGSQRASV ISAAAGCSVA
     FATGNSNAGV NGWYLSMIEH KEAHSRLGFY GYDLQDQCGA ANSLSIRSDE GLIHELRGPN
     YPNYAMNVGH QPEYAGIAQA PHAARGDAFC VNPLIKIAFA DKNLSFDFLH PRKCIAKGAL
     REFEADGERS IILPAFSK
//
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