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Entry: A0A126R1N8_9EURY
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ID   A0A126R1N8_9EURY        Unreviewed;       550 AA.
AC   A0A126R1N8;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   ORFNames=SAMN02910297_00056 {ECO:0000313|EMBL:SFL15796.1}, YLM1_1379
GN   {ECO:0000313|EMBL:AMK15936.1};
OS   Methanobrevibacter olleyae.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobrevibacter.
OX   NCBI_TaxID=294671 {ECO:0000313|EMBL:AMK15936.1, ECO:0000313|Proteomes:UP000066376};
RN   [1] {ECO:0000313|EMBL:AMK15936.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YLM1 {ECO:0000313|EMBL:AMK15936.1};
RX   PubMed=27056228;
RA   Kelly W.J., Li D., Lambie S.C., Cox F., Attwood G.T., Altermann E.,
RA   Leahy S.C.;
RT   "Draft Genome Sequence of the Rumen Methanogen Methanobrevibacter
RT   olleyae YLM1.";
RL   Genome Announc. 4:0-0(2016).
RN   [2] {ECO:0000313|Proteomes:UP000066376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YLM1 {ECO:0000313|Proteomes:UP000066376};
RG   New Zealand Agricultural Greenhouse Gas Research Centre/Pastoral Greenhouse Gas Research Consortium;
RA   Kelly W.J., Li D., Lambie S.C., Attwood G.T., Altermann E.,
RA   Leahy S.C.;
RT   "The draft genome sequence of the rumen methanogen Methanobrevibacter
RT   olleyae YLM1.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SFL15796.1, ECO:0000313|Proteomes:UP000183442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16632 {ECO:0000313|EMBL:SFL15796.1,
RC   ECO:0000313|Proteomes:UP000183442};
RA   de Groot N.N.;
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
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DR   EMBL; CP014265; AMK15936.1; -; Genomic_DNA.
DR   EMBL; FOTL01000001; SFL15796.1; -; Genomic_DNA.
DR   RefSeq; WP_067147710.1; NZ_FOTL01000001.1.
DR   EnsemblBacteria; AMK15936; AMK15936; YLM1_1379.
DR   GeneID; 28489689; -.
DR   KEGG; mol:YLM1_1379; -.
DR   PATRIC; fig|294671.3.peg.1439; -.
DR   KO; K00399; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000066376; Chromosome.
DR   Proteomes; UP000183442; Unassembled WGS sequence.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000066376,
KW   ECO:0000313|Proteomes:UP000183442};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Transferase {ECO:0000256|PIRNR:PIRNR000262}.
FT   DOMAIN        3    268       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      315    441       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       147    147       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     257    257       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     271    271       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   550 AA;  60187 MW;  92572C47445B8783 CRC64;
     MADKKFLDAM TKKFKEAPDE RTTTFYNMGG WTQSERKTEF VNEGKSIAEK RGIPMYNPDI
     GNPLGQRALM SYQLSGTDTF VEGDDLHFIN NAAMQQAWDD IRRTVIVGLN TAHNVLEKRL
     GMEVTPETIT NYLEVVNHAM PGAAVIQEHM VETNPLLVED SYVKIFTGDD DLADEIDAAF
     VLDINKEFPE EQAEVLKSEV GGAIWQIVRI PSVVGRVCDG GTTSRWSAMQ IGMSMISAYG
     QCAGEGATGD FAYASKHAEV IGMGTYLPIR RARADNELGG VPFGFMADIC QATRVSDDPV
     KSSLEVVALG AALYDQIWLG SYMSGGVGFT QYATAAYTDN VLDDFSYFGK DYVEDKYGGL
     CEAPNNMDTV LDVGSEVAFY SLEQYEEYPA LLETHFGGSQ RAAVISAASG ISTAFATGNA
     QTGLSAWYLA QYLHKEQHSR LGFYGYDLQD QCGAANVFAI RNDEGLPLEL RGPNYPNYAM
     NVGHQGEYAG IAQAPHSARK DAYAVNPLVK IAFADKNLAF DFTKVRAEFA KGALREFEPA
     GERSIIIPAK
//
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