ID A0A127A3B9_9MICC Unreviewed; 717 AA.
AC A0A127A3B9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=SA2016_2931 {ECO:0000313|EMBL:AMM33596.1};
OS Sinomonas atrocyanea.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Sinomonas.
OX NCBI_TaxID=37927 {ECO:0000313|EMBL:AMM33596.1, ECO:0000313|Proteomes:UP000070134};
RN [1] {ECO:0000313|EMBL:AMM33596.1, ECO:0000313|Proteomes:UP000070134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 3377 {ECO:0000313|EMBL:AMM33596.1,
RC ECO:0000313|Proteomes:UP000070134};
RA Kim K.M.;
RT "Complete genome of Sinomonas atrocyanea KCTC 3377.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP014518; AMM33596.1; -; Genomic_DNA.
DR RefSeq; WP_066499344.1; NZ_CP014518.1.
DR AlphaFoldDB; A0A127A3B9; -.
DR STRING; 37927.SA2016_2931; -.
DR KEGG; satk:SA2016_2931; -.
DR PATRIC; fig|37927.3.peg.3011; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000070134; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000070134}.
FT DOMAIN 77..263
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 364..644
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 717 AA; 75615 MW; FDCD7537EC811FC7 CRC64;
MASGRKVLRS TSLGVGRILS FLAVSLLCGV LTAGLMSPAV ALAGSATNGS VQFFDSLPSD
LEVTPPAQVT RILAADGSVI GSVFSENRTN VPLEKVSQSM RDAIVAIEDY RFYEHGGIDP
MGILRAFASD VGGAHQGAST LTQQYVTNVL NEDLVAQGQG SDVVLNGQKG VGDKLREMKL
AISLEKKESK DKILQGYLNI VSFSGNAYGV QAASQYFFSE DAKDLTLTQS ALLAGLVNGP
GYYDPVAYPD RAVGRRNLVL DAMLEHGYIT KAQHDDAVKA PLKLKLNPPK QGCAYAAQAP
YFCDYVLHQI LNDPAYGATP ADRERRVDRG GLTIRTTLDP RLQGPAQTQV DATAGANPDK
WGASLVTVQP GSGKVLAMAQ NSRVLAGQGT GFLTSYNFNV DRTDPSGNQL GGVGGMQPGS
TMKPATLAAW LDEGKPTDQI VNAAQRRYPP GYPWKTTCGR VSGSFDSAVA GSVDLQNDEP
GWYRPMTVRE GIYQSINTAT FASAAALDDF CDIQRAADAM GLHDGAGGGK KLDLSVLGNI
LGASNVAPLT MADAFATFAA DGTYCAPMSI TEVDDAKGQK IGGQAPSCQA GALKPDAAKA
ATNVLEDVIK KGSGLLIPQK LGVPDAAKTG TNQYNNQTWV VGYTRGLATA SFFGDPFNGS
DARLGRNVTV NGKYYPVIDG AYIAGPQWAT YMQKVLGFYD HGAFDAPPQN LIRPASH
//
