ID A0A127A5K9_9MICC Unreviewed; 408 AA.
AC A0A127A5K9;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:AMM34376.1};
GN ORFNames=SA2016_3718 {ECO:0000313|EMBL:AMM34376.1};
OS Sinomonas atrocyanea.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Sinomonas.
OX NCBI_TaxID=37927 {ECO:0000313|EMBL:AMM34376.1, ECO:0000313|Proteomes:UP000070134};
RN [1] {ECO:0000313|EMBL:AMM34376.1, ECO:0000313|Proteomes:UP000070134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 3377 {ECO:0000313|EMBL:AMM34376.1,
RC ECO:0000313|Proteomes:UP000070134};
RA Kim K.M.;
RT "Complete genome of Sinomonas atrocyanea KCTC 3377.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP014518; AMM34376.1; -; Genomic_DNA.
DR RefSeq; WP_066500973.1; NZ_CP014518.1.
DR AlphaFoldDB; A0A127A5K9; -.
DR STRING; 37927.SA2016_3718; -.
DR KEGG; satk:SA2016_3718; -.
DR PATRIC; fig|37927.3.peg.3812; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000070134; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:AMM34376.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070134}.
FT DOMAIN 68..343
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 408 AA; 44481 MW; BE25FAE9F9BC50E8 CRC64;
MGVELPTTEF SDIPDELAME LEAHAHDGAE GHGAMVQLLD EDGRFRRDSK LAESIKGLSE
DSLQGMYRQM AMIRRFDTEA TALQRQGQLA LWVPLRGQEA AQIGSGAATQ AQDYVFPTYR
EHGVALTRGV DLAELLRLFR GLSNGGWDPR ATGFHLYTLV LAAQTPHAVG YAMGMQRDQA
RAAARGEEAG DPGAVVAYFG DGASSEGDVH ESMVFAASFK APVVFFCQNN QWAISVPAEV
QSRIPLFNRA KGYGFPGVRV DGNDVLAVYA VTQWALERAR AGKGPVLIEA YTYRQGAHTT
ADDPTKYRLS DEEQSWLAKD PLARFEKHLR AEGIADEAFF EQVAADGDAL ATKARADILE
FTAPVLADAF ANVYAEPHPL VEQELAWHRD YEAGFADAAA EATREGGR
//
