ID A0A127VEG4_9SPHI Unreviewed; 2631 AA.
AC A0A127VEG4;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Nonribosomal peptide synthetase {ECO:0000313|EMBL:AMP99732.1};
GN ORFNames=AY601_2854 {ECO:0000313|EMBL:AMP99732.1};
OS Pedobacter cryoconitis.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=188932 {ECO:0000313|EMBL:AMP99732.1, ECO:0000313|Proteomes:UP000071561};
RN [1] {ECO:0000313|EMBL:AMP99732.1, ECO:0000313|Proteomes:UP000071561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PAMC 27485 {ECO:0000313|EMBL:AMP99732.1,
RC ECO:0000313|Proteomes:UP000071561};
RA Lee J., Kim O.-S.;
RT "Complete genome sequence of Pedobacter cryoconitis PAMC 27485.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP014504; AMP99732.1; -; Genomic_DNA.
DR RefSeq; WP_068402155.1; NZ_CP014504.1.
DR KEGG; pcm:AY601_2854; -.
DR PATRIC; fig|188932.3.peg.2975; -.
DR OrthoDB; 4317020at2; -.
DR Proteomes; UP000071561; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45398; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR PANTHER; PTHR45398:SF1; ENZYME, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000071561}.
FT DOMAIN 1037..1114
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2093..2167
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2631 AA; 295650 MW; DD22F2A91F01C2AE CRC64;
MKDIKSIMTA LRKLNVNLSL TNGVLEITSH EVKMPQDLLE SIELHQEKLV AYLKKNLISR
DFNHILPVEN GANYALSSSQ RRLWIQSKFN TESVAYNMSS AYVFEETFSR DAIEYAFTAL
IERHEILRTV IREDESGEVR QFIQLPESSG FKLSFYDLCQ DQDAEDRAKE LVSLDFSRNF
DLEKGPLIRA GLYQISEQRW IFSFVMHHII SDGWSMGILI RELLQLYHSY LNGLGNPLVP
LRIQYKDYAA WQQEQLNGTS LEGHRSYWLE QLSGELPVLD LEGDQKRKSV RSYAGGVANR
TLSKDDAAGI KGLSQGENGT LFMGLLAALN TLLYKYTQQT EMIIGSPIAG REHADLEGQI
GFYLNMLALR GRFKGEDSYL SLLRHFREVT LGAYEHQVYP FDELVGSLNI AHDQSRNALF
DVLIDFHDNR NAGGQELNNL KVSSFTGGEH VVSKFDLTFM FMESDQELSL SIEYNSDLYS
RAYVERMHDH FAQLLSAIVA NPDLPVQELN YISKAEENVL LNSFNANFDS GETYRSVLSL
FEEQVSINAG DMALSYDGLT LSYHELAAKS NQLAHYLKEE YKLQQGDMVG IMQERSDKLL
ISILGILKAG GVYVPIDPDY PQSRKEYILE DTGLQILLTQ TSYMFDLSYY EGNVFAVDIQ
LDELGTSAAP VVDEIAEEDM AYIIYTSGST GQQKGCCVSH GSLANYIQWA NSYYFDGTVK
GNFGLFTSLS FDLTVTSIFC ALTGGGSLYI YNQEKSLSDI FTHTLSLESG IDSIKLTPSH
IRYLKDLNLS SESLKCAIVG GEEVVSKHVE ILKQINPGMR VYNEYGPTET TVGCTVQELE
AGEAVHIGRP ISGAAAYVLD ENLRLCAIGV SGELCISGAG VSLGYLNKEP LSREKFVADP
YRLGQRLYRT GDTGRWASDG TLIFLGRKDD QVKIRGYRIE LGEIEQALLR HPDIDSSAVV
VKAGGDGDHE LIAYLTGSEP LLIGEIRTYL HRVLPAYMIP SLFVQLDSMP LTINGKIDRK
QLPDPGKGMN SGTVYVAPVN ETEEQLVNIW SEVLGIDKDQ IGTKSDFFEL GAHSLKAIRL
TSQIYKEFDV KIDLKDVFVT KTLEGQAELI LKAKKVAYIN ILPVENGANY ALSSSQRRLW
IQSKFNTESV AYNMSSAYVF EETFSRDAIE YAFTALIERH EILRTVIRED ESGEVRQFIQ
LPESSGFKLS FYDLCQDQDA EDRAKELVSL DFSRNFDLEK GPLIRAGLYQ ISEQRWIFSF
VMHHIISDGW SMGILIRELL QLYHSYLNGL GNPLVPLRIQ YKDYAAWQQE QLNGTSLEGH
RSYWLEQLSG ELPVLDLEGD QKRKSVRSYA GGVANRTLSK DDAAGIKGLS QGENGTLFMG
LLAALNTLLY KYTQQTEMII GSPIAGREHA DLEGQIGFYL NMLALRGRFK GEDSYLSLLR
HFREVTLGAY EHQVYPFDEL VGSLNIAHDQ SRNALFDVLI DFHDNRNAGG QELNNLKVSS
FTGGEHVVSK FDLTFMFMES DQELSLSIEY NSDLYSRAYV ERMHDHFAQL LSAIVANPDL
PVQELNYISK AEENVLLNSF NANFDSGETY RSVLSLFEEQ VSINAGDMAL SYDGLTLSYH
ELAAKSNQLA HYLKEEYKLQ QGDMVGIMQE RSDKLLISIL GILKAGGVYV PIDPDYPQSR
KEYILEDTGL QILLTQTSYM FDLSYYEGNV FAVDIQLDEL GTSAAPVVDE IAEEDMAYII
YTSGSTGQQK GCCVSHGSLA NYIQWANSYY FDGTVKGNFG LFTSLSFDLT VTSIFCALTG
GGSLYIYNQE KSLSDIFTHT LSLESGIDSI KLTPSHIRYL KDLNLSSESL KCAIVGGEEV
VSKHVEILKQ INPGMRVYNE YGPTETTVGC TVQELEAGEA VHIGRPISGA AAYVLDENLR
LCAIGVSGEL CISGAGVSLG YLNKEPLSRE KFVADPYRLG QRLYRTGDTG RWASDGTLIF
LGRKDDQVKI RGYRIELGEI EQALLRHPDI DSSAVVVKAG GDGDHELIAY LTGSEPLLIG
EIRTYLHRVL PAYMIPSLFV QLDSMPLTIN GKIDRKQLPD PGKGMNSGTV YVAPVNETER
ALVEVYEEVL KKEYIGMKDD FFALGGDSIK SIQIISRLRK KGYSVSIQDI LLLPVLDDLK
EKIKLVTRKI DQDIIEGEIL LSPIQQYFFG NSSEDAHHYN QSVLLESKDE ISEEGIKKVF
DKIVHHHDAL RMVYQNTSNG WKQMNKGIDQ GYVFEIIDNY TESSFIEECE RIQSTLDLEK
GPLFKVCLFR KPGEHRLLIL AHHLIIDGVS WRIIFEDLSS LYQQYLSGEP LVIPLKSDSF
KYWMEKQEEY KTHTDLLNEE PFWTAIGVTK TDPLPLDHPL GTNLRSDAVI KSFNVNQELT
KKLLTQCHHA YQTDTNDILL AVLSLSIKEI FSLDKIVINL EGHGRESIGN EVDVSRTVGW
FTTMYPVVLE INNDEDLIKH LVTSKEVLHR VPNKGIGFGI LRYLAGKQYE IDPQINFNYL
GDFGTGIENA EGSRLFDFVG EYHGMESSGN RRRDSILNVS GIIVDSKISI LIEFSNKQFD
DATIEDLLQS FQRRLENFIV LLSEEDKTTL SPVDLTYKGL NQAQLEELSR S
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