ID A0A127VZV6_SPOPS Unreviewed; 715 AA.
AC A0A127VZV6;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Penicillin-binding protein {ECO:0000313|EMBL:AMQ06802.1};
GN ORFNames=AZE41_13120 {ECO:0000313|EMBL:AMQ06802.1};
OS Sporosarcina psychrophila (Bacillus psychrophilus).
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Sporosarcina.
OX NCBI_TaxID=1476 {ECO:0000313|EMBL:AMQ06802.1, ECO:0000313|Proteomes:UP000071057};
RN [1] {ECO:0000313|EMBL:AMQ06802.1, ECO:0000313|Proteomes:UP000071057}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6497 {ECO:0000313|EMBL:AMQ06802.1,
RC ECO:0000313|Proteomes:UP000071057};
RA Yan W.;
RT "Complete genome sequence of the Sporosarcina psychrophila DSM6497, a
RT psychrophila Bacillus that can mediate the Ca2+ precipitation.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP014616; AMQ06802.1; -; Genomic_DNA.
DR RefSeq; WP_067210201.1; NZ_CP014616.1.
DR AlphaFoldDB; A0A127VZV6; -.
DR STRING; 1476.AZE41_13120; -.
DR KEGG; spsy:AZE41_13120; -.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000071057; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR Gene3D; 1.10.10.1230; Penicillin-binding protein, N-terminal non-catalytic domain, head sub-domain; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..309
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 356..680
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 694..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 80108 MW; 5B43E9097B8C15AC CRC64;
MKKQVRKADQ AKIRQRKHIA FRMNFLFFSI FVLFSLLIFR LGYLQIVKGE EYSRELEKKE
EIPINTSVPR GKIFDRMGRV LVDNDPKNAI TYTKMTSTTS ADMLKVAEQL AILIEQDTKR
ITIGDKRDFW ILKNSEAALK KVSIKEQEAL EKDSTLSRTE LQKEINRLTR ERITDEEIDS
FTEEELEVLA IYREMMSGYA YSPQIVKSGN VTDEEFATVS ERLGELPGVD TTTDWERVRK
SDNTILGTTT SPIEGIPKSR EKYFLARDYS RNDRVGKSYI EQYYEDLLKG QKTIVKNIKD
RSGRVVETKT IRQGEPGKDL ILTIDSELQE TLENIVSDKL LELKRKPNTG ELDRAFLVMM
NPNNGEVLSL VGKQVVTNPE TGKLEIWDYA FGTFTALHEA GSTVKMATLL TGYQENVVRI
GETKIDEPIR IGGITKRSLF NQNSRVAVTD IEAIGRSSNV YMFRIALALA NSNNSSEDSA
LIRKNAFDTF RQSFASFGLG TKTGIDLPGE SGGLIGDSNS IGILLDLSIG QYDTYTTLQL
AQYVSTIANG GYRVAPKVLK EIREPSEDGK ILGPLIQETE VNILNRIQNT DAEIAQVKRG
MHYVYYGAKG TAPNFFAGKE YDGAGKTGTA QAFSSGKPTI NLSHVGFAPY ENPEIAYAVV
IPNISTVPRG YTYANNQIAE QAVDEYFKLK AKRAKEETST AAKQPIIQAP KVESN
//
