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Database: UniProt
Entry: A0A131ZZN1_SARSC
LinkDB: A0A131ZZN1_SARSC
Original site: A0A131ZZN1_SARSC 
ID   A0A131ZZN1_SARSC        Unreviewed;      1221 AA.
AC   A0A131ZZN1;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=QR98_0025860 {ECO:0000313|EMBL:KPM04144.1};
OS   Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Acari; Acariformes; Sarcoptiformes; Astigmata; Psoroptidia;
OC   Sarcoptoidea; Sarcoptidae; Sarcoptinae; Sarcoptes.
OX   NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM04144.1, ECO:0000313|Proteomes:UP000070412};
RN   [1] {ECO:0000313|EMBL:KPM04144.1, ECO:0000313|Proteomes:UP000070412, ECO:0000313|VectorBase:SSCA009908-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM04144.1};
RX   PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA   Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT   "Draft genome of the scabies mite.";
RL   Parasit. Vectors 8:585-585(2015).
RN   [2] {ECO:0000313|VectorBase:SSCA009908-PA}
RP   IDENTIFICATION.
RG   VectorBase;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; JXLN01007572; KPM04144.1; -; Genomic_DNA.
DR   EnsemblMetazoa; SSCA009908-RA; SSCA009908-PA; SSCA009908.
DR   VectorBase; SSCA009908-RA; SSCA009908-PA; SSCA009908.
DR   OMA; GNDTWYG; -.
DR   Proteomes; UP000070412; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000070412};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:KPM04144.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070412};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     17     41       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     62     79       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     91    115       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    147    170       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    219    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    540    562       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    568    588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    617    643       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    736    762       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    823    840       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    852    874       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    886    905       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    949    973       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1034   1056       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1077   1112       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1221 AA;  141370 MW;  445953DF568C74D9 CRC64;
     MLCVWDCFWC WIRVQELVAL VVFDPFMELF ITLCIVSNTL FMAMDHHNMD KDFENILQKG
     NYFFTAIFAI EAMMKLMALS PKFYFREGWN IFDFVIVVLS LLDVSLSSVS GLSVLRSFRL
     LRVFKLAKSW PTLNLLISIM GKTIGDLGNL TFVLVIIIFI FAVMGMQLFG KNYTEESFGG
     KEIPRWNFKD FMHSFMIVFR VLCGEWIESM WDCMRVSGAA CVPFFLATVV IGNLVVLNLF
     LALLLSSFGA SNLSAPTSES ADTKKLQEAF DRFSRGGKWI KHRTLSFPKT RNQIRDQICD
     HSISYEEMLK TSNKIDQTSE IILVENEKNQ QISPSISIPN ANNMKATTIL PNVNLEMVHL
     IQNQNDLNKI NGTNSQTKSI INRKENNDAQ ISRKNSMNVN FESDLSRKIS MDTEIIVKDE
     KFSSLDSNLI QGESRSDVIK SIEVNGKLDA ATADVVINEY PSECWPEPMY QYCPWCLDET
     TFWARWKTIR SKCYKIVEHK YFETLVITLI LISSMALALE DVNFKKDPLF MEYLNYVDKF
     FTIIFICEML IKWLAFGFYG YFTNVWCWLD FVIVMVSVIN LIATWFGVAR IQAFKTMRTL
     RALRPLRALS RFQGMRVVVN ALIQAIPAIF NVLLVCLIFW LIFSIMGVQL FLGKFYQCID
     AKTKIRLNAS YVPNKEACEA RNHTIWYNPP INFDNVLNAY LALFQVATFK GWTDIMNNAI
     DSKQELDEQP EKEVNLYMYL YFVFFIIFGS FFTLNLFIGV IIDNFNEQKK KAGGSLEMFM
     TEDQKKYYNA MKKMGSKKPM KAIPRPRFKL QAIVFDVTTN KKFDMIIMLF IALNMFIMSM
     DEYRQNPTVS IILERLNLFF IAIFTAECLL KIFALRWHYF KEPWNVFDFV VVILSILGVL
     LRDIIAKYFV SPTLLRVVRV VKVGRVLRLV KGARGIRTLL FALAMSLPAL FNICLLLFLV
     IFIYAIFGMS FFMNVKQRYG IDETFNFSTF SRSFILLFQM STSAGWDHVL AAIMDENDCT
     PTGPENEGDC GNKGIAIAFL VSYLIISFLI IINMYIAVIL ENYSQAAEDV HEGLTDDDYD
     MYYEIWQKFD PKGTQFISYH QLSDFVHALE EPLQIPKPNK FKLISMDIPI CVEDMCYCVD
     ILDALTKDFF ARKGHVIEET AELAEVAPMK LGQFEHISST LWRQREVYCS KIIQKVWRDY
     LKRKKQFATN QSRLNTIEEE S
//
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