ID   A0A132A0A1_SARSC        Unreviewed;      4457 AA.
AC   A0A132A0A1;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=ABC transporter sub-family A-like protein 5 {ECO:0000313|EMBL:KPM04321.1};
GN   ORFNames=QR98_0027640 {ECO:0000313|EMBL:KPM04321.1};
OS   Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC   Sarcoptidae; Sarcoptinae; Sarcoptes.
OX   NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM04321.1, ECO:0000313|Proteomes:UP000616769};
RN   [1] {ECO:0000313|EMBL:KPM04321.1, ECO:0000313|Proteomes:UP000616769}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM04321.1};
RX   PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA   Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT   "Draft genome of the scabies mite.";
RL   Parasit. Vectors 8:585-585(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KPM04321.1}.
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DR   EMBL; JXLN01008229; KPM04321.1; -; Genomic_DNA.
DR   VEuPathDB; VectorBase:SSCA009721; -.
DR   OrthoDB; 3108829at2759; -.
DR   Proteomes; UP000616769; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03263; ABC_subfamily_A; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC2_TM.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229:SF185; ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR   Pfam; PF12698; ABC2_membrane_3; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          3250..3487
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          4257..4456
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   4457 AA;  513453 MW;  7E77B667EA46D33A CRC64;
     MENFLSLFQL SIDSVVDQVL PLLTNDNITK VINDLPKGIR LIAALIDTLS KSSVQQLLQN
     GLPLKSMLRP AAWKLIQQKL AQFESNSVPI YDLDSTNLFN DYDENLNPLI STYDILVNAN
     LNLMQFGLHS DNSISQTFRS FRDVICDQKQ LEKFLIVPQK FYITLLSRNL CLLERKDLYH
     LFDLIQDNID FVNLLSKLSL IFESVGLNQQ RKHLDNIIEM LETIDRANLF SSLNVLQNTS
     WMYDVPILFD FVRSGEINVS TLLKIFNDIE PIFNTEDSMQ QNHQLNEQRQ RHQIEILMRL
     YESDDSNLKS FSSTTSSSSS SSSSSSSPSS NSSSSSSSSS NSDDLIGDSD YVFDQDFDQS
     NESDDDQTVE EEKFNEEPIV QDDDLEASES NVNLFSIATD NYQRENLDRK FWPKILSNMD
     RFIDGAEKFT KTSQWNSLLG TFKGFEMMLE MIDSGKAMDQ FSSETIERLI LNLPKNIQLI
     SNFFNSIVPE KFQPLVTPLI SLFERISDSM LKHLSGAFLR ALRENKIFYF DKMAQFLIES
     VDNGTLPRKC IDMQRAMCDY DTFKSVFVYD SDDESDESEM YFDDEDTGTL QGIQQLGCIF
     FGQNYWQQDV EESAPTIAKL LYTLSTLNDT DQLSSSLTAL AFGNIGNFTT NDESDTFWNN
     FAPRMLEIYL LATKSVDSNS WNRIISELSN VWKRNRLFDR LILGSRVLQL IANCFTPERI
     MNSPIWFSIQ RKNIIINEIL NLILDELNQA VENESFRVQQ LAMGSPTLNH FLHKHLHIIP
     ILLDSIADTL FNNFPLFIER MFEFYNAFKS NWPCNRFSIV DMLSIQNEEH KLEVYTVEDF
     LCRQTRMSEG EYGRIIDELI EPYNNQSRAA PLIRVLQHKS NNLSRVYEFV PQLDWVEAAT
     TIFSIKESAE KLIFSGGEMI WFPEIERLDS LIRNSLNRIR SFLIEFYNQG NMKMFTYFGD
     IITPFAIRYL SLNETFSEIC DYGISGQLMA PVITDKEWRC FFVSTRFISY SMQYLLHLSN
     DVMGTFLNNS NECRLFDLDR SIEENDILFL SDHLPELIEL IFNQIFFTDI NILARTTSLN
     QLVCESNTNL NIFGPHGALY EKLRHSICRV PIESAKCLRL MMFDRWTDAF DHLNRSWYTQ
     SLVDLSHRSA FVDTYHSLYR FISLFGQFSP QFINQFRLKF HSSQNGPQFL KDVLKKINKI
     EQFRGKRFAY ILQTLSVEVN RFLFDSTRSM RFQKKTEEKR EIIMALIYAL NEIPQRLRQR
     YKLGAIHFKP QTIIDELLQA DLLDSVLDWF DSNLIVVSEI LLQTIVLEPQ KLSRLFVNKF
     DAILIWRAFC RAPVDQYLLI ENRSLNNARQ AKDEICGIDF NFVYNQWYRR SQPFLVNYTN
     EELISVILYQ IGSSIDLIAK DNVYRHGLLK SNEWPPIIAR MNQLTSKSNP IEWIVESSAS
     LMQTYLSKSS IETIQKVMSK LRCGIETIPY EGMSWEIVPQ IYSNKTEIMS LYSTLNSAFT
     IISIGLNTFL TQTKYYNHLH MMAKFGSKNG FCQLETDQDF KEVFAIVPQS SADEIFQTLR
     SLQSFVCRQS SRFWSNLNPV SKCYEFDSSS ATNFRYVQND LRLFIERLRS TSEPKKSELE
     FEDQNQMTKI PLLDLQQWNR LFKWWSDEIA PYGNSARTLL MMRIFESIDV FADQHVIWKA
     FYRLTYMTSE MLAYSLRALQ LTDSMYPSKA EIKINLNKST IEVLKEFSHK NGLSSLLTSA
     VSNLIFPEVN HFITFTTFRQ LRWIKHISHF FAKHPDILHD ELCPALVRIN TNQQNLTTDS
     SLIVNDDFND LLLLLCHNHP SDWIYSLTFK SNLFNIKTSP KPKFISHRKI RERIGKLTQV
     LARMLDYNSN KNNQKLDHVI KFLKKKQLES IENVAGAVDI MIQTIMLTQN QTSHRILSFK
     EILKSGWQSV PIILDSIDQY ICSYKTNDFN RNTPILDVRN DFLYRPRAPD MKILLCEIPR
     WNFDQAYSYL SKHLDVKNML LMFSANEIDS NSNNGNENCS GNKVGDRKQC QNRSQCVTML
     RFLSRWIDVA QKIFDQIYDQ SFWSELKACR KRHLFSLLAS SKSSNTFLVR HSLRYVRFMN
     KLLSTIDRFS HENDGVSWNN IRQLWRTFSF FTLNQVPLYV PITDIIRADI NLPEYLNATL
     DRVSTLSRSR AKQAIRLLTD SMLDINAISM NKFNNIALKE MICKKRETIR FLDSKSYHLP
     IMVKSITSEN RTSNVIDQSK QESLYETLCN INDFIPIIDS LMSAIDPNTM INQVEKLRRF
     KASKNNWIND VLMPEMTEMI ASGAFAKIPN KIKIIQNSDQ IKTKSLSQKG INHLLISFVS
     MTKAKNFNNL YNAIKQAIEQ FSPKLNDGPI IGVLNQILEG LQSIKELASS GLFQIKYKIS
     ELLVNSENVK IFLEKNLGLP KHFIGQILNS TIDLSEFIEM SAMVSFDSSA FCNQTLLFDE
     LKIKLPFVIE SKSRPSKEII TNAICTLSVT EDLKFNNQIL NQLVIRKLTF NIVDLIQNSL
     WNKAKIDSSQ VPRALNAIKI SSYSMPQIKS FVRAMNHSFD KIIDDQFLSM NLNNLSLSNV
     SKFVGNLFCG KISSTFDQHI DMLKVKVHTP KLSTIETFAT DFCSDGYKQI INLQGGPVIW
     NFLKPILVGK ILYSPKAPVT DSIISRMNTT LQFMPKIIEM LDAWSQTLSS LETFYQSDVN
     HKMNHVKHLI ETIFVNGEAD GLLDDIDTLK LIEKMTKSGN ILSFVKLVGK ISQCVSFDRF
     VGVENELQLE ELARNLTKSH EFIAGIVFVG DKDVYLNEKT VPKEIEYKIR IDVDFIPSTK
     SLKARIWEPG PRDNYLKELK YMHGFVQIQE MLDRSIISFW TNHSTLSIDP EVLLQQQPYL
     CHESDRFGNY IRSLTPLITT MAWIFLIAYL IRENVLEREL HLDEVMQVMG LKSGVAWLTW
     FLIGLSVMTF ASFVGISLLS IGQLIPASDP ILLFLFFMAF NVSLLMFCYM ISSFFRTSTI
     AALSGIVAYL ASFLPFMVVI TLENEMNFFQ KLITCFSMST SFCFGMMYMT RFEVQGVGMQ
     WNNFWHSPMQ GDPMSVGAAM IMMMIDSIVY FLIAWYVSHV FPPGNNARRY TPLFFLSYSY
     WKYDFLRSIG MDKTKPLLNW SPEIDSLYSL EKYDCIENDQ IVEKDIIEEI ENTSLVLEND
     GTFNIVDPEE WKSLSSKAFF NSNLDDNAMI ADGTLKTISG TIRKAIANST VIRKSSQQSI
     STLNQGPLGM EINGLYVIYN ENNHNTKHIA VSNLNLNLKE GQITTILGRN GAGKTTTINV
     LTGQMLPTSG TVKIYGHRIP DQFSCARKLL GYCPQYNTLF NDLTVREHLE FFSKLKGLLK
     EPQAIQDDVD EILKNMDLWD LQDQLAKHLS GGLKRRLCVA LAFVGGSKLI ILDEPTASVD
     PVARRKIWDL IVKQKRSRTI LLTTHHMDEA DILSDEVAVI YRGKLLCSGS PLLLKSKYGC
     GYRLTVSRQG RSDHSGYDSF DESSSRDQRS SEENDSLDSR ITLRTCSDVE KLMAFAKCLI
     PNASFVEDNN GEVILSLPHE DDLGEPHDYA TFFRCFDSNI RTLGFGSYGV TSTTLEEVFL
     TLCNLEESKI PVDKAKLAVA RRFNPPSYAN SIRSSFQNNH QLSSTMNSRE DDQQEIQFDQ
     GLSLKFRQLY ALLLKRFLHM IRDWRLLFCT LFLPCIFIAF AMAMTLIKPT FAPDPALLLD
     PQIYGQSTVS YFQNNHKHDE FETKFETIEQ QLMAHKFDKI DCLEPHEKWR TAKCPILNQN
     VAELPEHLKT FSSNSWRRKS RTSCKCTECF ADLKTIGNFV PPPQQTPGGW LYNLSRIVDL
     NQFLLSTQPE FMDRRWGGIS FRSAKVNRSS HPRRRMVKIW FDNNGFHTIP SYLNTFNNAL
     LRANLKESGF ANVSMYGIKT YSHPLHVRSN QLGDQSVMQQ AGDAGIAIII LVGFIFIPTS
     FVFYIVRERI YEEKHLQKTF GVGPLLYWLS SLLWDVLILI VAIIFSSAII IFFQLPIYMS
     RLNLPAILTL LFFFGWAMIN FVYVLEKFFN EPSLAFTGIY CLALFIGIQT MVMRLMIDVF
     KLIEITPLIY KTFEKIAILF PPYLLLSGIV DIHRNQLFAD IFVLFDQDIY VNPFSFDLLG
     KHFTIFALQG LVLFVLNYLI ESDQLPRFGL FRSINQSTIE QESLRSLQDE DKDVAEERRR
     VHSSRESSLI QDSNSQSNSA HSDDLKTETN RRDSNDYSLT NTISNSNNSL DSSTDILKVL
     EVSKLFENMF GYRCAVKNIS FSVPRGECFG LLGVNGAGKT TLFRIITGQM EATTGETIFN
     GRNIREAISM CSKEQSIGYC PQADALDDFL TPIEHLTIYA HLRGIPQHQI SKFVNESIDK
     FQLQPHSSMP VQTLSRGNRR KLCLALAMLG RPQLILLDEP TSGLDPQSRR HVCQNIQDAI
     RDRRSILLTS HRSLSAR
//