ID A0A132A3D4_SARSC Unreviewed; 356 AA.
AC A0A132A3D4;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Activator of 90 kDa heat shock protein ATPase -like protein 1 {ECO:0000313|EMBL:KAF7488209.1};
DE SubName: Full=Activator of 90 kDa heat shock protein ATPase 1-like protein {ECO:0000313|EMBL:KPM05508.1};
GN Name=SSS_283g {ECO:0000313|EMBL:KAF7488209.1};
GN ORFNames=QR98_0039720 {ECO:0000313|EMBL:KPM05508.1}, SSS_283
GN {ECO:0000313|EMBL:KAF7488209.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM05508.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM05508.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM05508.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
RN [2] {ECO:0000313|Proteomes:UP000070412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=33001992;
RA Korhonen P.K., Gasser R.B., Ma G., Wang T., Stroehlein A.J., Young N.D.,
RA Ang C.S., Fernando D.D., Lu H.C., Taylor S., Reynolds S.L., Mofiz E.,
RA Najaraj S.H., Gowda H., Madugundu A., Renuse S., Holt D., Pandey A.,
RA Papenfuss A.T., Fischer K.;
RT "High-quality nuclear genome for Sarcoptes scabiei-A critical resource for
RT a neglected parasite.";
RL PLoS Negl. Trop. Dis. 14:0-0(2020).
RN [3] {ECO:0000313|EMBL:KAF7488209.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SSS_KF_BRIS2020 {ECO:0000313|EMBL:KAF7488209.1};
RA Korhonen P.K.K., Guangxu M.G., Wang T.W., Stroehlein A.J.S., Young N.D.,
RA Ang C.-S.A., Fernando D.W.F., Lu H.L., Taylor S.T., Ehtesham M.E.M.,
RA Najaraj S.H.N., Harsha G.H.G., Madugundu A.M., Renuse S.R., Holt D.H.,
RA Pandey A.P., Papenfuss A.P., Gasser R.B.G., Fischer K.F.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblMetazoa:KAF7488209.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AHA1 family.
CC {ECO:0000256|ARBA:ARBA00006817}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; WVUK01000066; KAF7488209.1; -; Genomic_DNA.
DR EMBL; JXLN01010331; KPM05508.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132A3D4; -.
DR EnsemblMetazoa; SSS_283s_mrna; KAF7488209.1; SSS_283.
DR VEuPathDB; VectorBase:SSCA007320; -.
DR OMA; CEVNQRK; -.
DR OrthoDB; 5473696at2759; -.
DR Proteomes; UP000070412; Unassembled WGS sequence.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0001671; F:ATPase activator activity; IEA:InterPro.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:InterPro.
DR CDD; cd08892; SRPBCC_Aha1; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.15.10.20; Activator of Hsp90 ATPase Aha1, N-terminal domain; 1.
DR InterPro; IPR036338; Aha1.
DR InterPro; IPR015310; AHSA1-like_N.
DR InterPro; IPR013538; ASHA1-like_C.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR13009; HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1; 1.
DR PANTHER; PTHR13009:SF8; LD43819P; 1.
DR Pfam; PF09229; Aha1_N; 1.
DR Pfam; PF08327; AHSA1; 1.
DR SMART; SM01000; Aha1_N; 1.
DR SUPFAM; SSF103111; Activator of Hsp90 ATPase, Aha1; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000070412};
KW Stress response {ECO:0000313|EMBL:KPM05508.1}.
FT DOMAIN 29..164
FT /note="Activator of Hsp90 ATPase AHSA1-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM01000"
FT REGION 192..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 356 AA; 41163 MW; C30FF1607E36BAA2 CRC64;
MAKWGEGDPR WIVEERPDAT NVNNWHWTEK NASHWSKEKL KALLVDQIIE DPGLGRCILV
EMTSCNGEAV ANNRKGKLIF FYEWEVEIKW VGRLHGSSDE YTGKVSIPNL SEENTADEIT
FNISSDQDLP QTDLLKNMIR TVGNEILKDK MRQYINDLRN EFAKDMIKPT KLSEDGNINI
FLTENQIESK KSVTKTNSSS NTSMKKFCPE SKNNDDMSQK TLHTTSIRLS DHFKCQAKDI
YEIFTESHLL QAFTQNKVEN NPSIGEKFSL LGGNIVGTYT YLEPYKCIKQ NWRISNWPEK
HFSEVVINFD QKADSTEILI EQNGVPETEY DRTIEGWKRN YLESIKRTFG IGYSIY
//
