ID A0A132A5P5_SARSC Unreviewed; 1242 AA.
AC A0A132A5P5;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=QR98_0047550 {ECO:0000313|EMBL:KPM06281.1};
OS Sarcoptes scabiei (Itch mite) (Acarus scabiei).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Sarcoptoidea;
OC Sarcoptidae; Sarcoptinae; Sarcoptes.
OX NCBI_TaxID=52283 {ECO:0000313|EMBL:KPM06281.1, ECO:0000313|Proteomes:UP000616769};
RN [1] {ECO:0000313|EMBL:KPM06281.1, ECO:0000313|Proteomes:UP000616769}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:KPM06281.1};
RX PubMed=26555130; DOI=10.1186/s13071-015-1198-2;
RA Rider S.D.Jr., Morgan M.S., Arlian L.G.;
RT "Draft genome of the scabies mite.";
RL Parasit. Vectors 8:585-585(2015).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPM06281.1}.
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DR EMBL; JXLN01010752; KPM06281.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A132A5P5; -.
DR VEuPathDB; VectorBase:SSCA008907; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000616769; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}.
FT DOMAIN 1073..1089
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 1242 AA; 144169 MW; F7FF1180116D0E26 CRC64;
MIGQLHLIDC ESGNDSSDRE NTPRSNFNQT PKRKNRIDHN EDECSDDDDF LRRKKTSKKF
KHNLSDSDES EDDGDEYQPD HVEESSEISE SDDDSSSLES DHIDSEDSVS SKKVKFIKKF
SHSKQSLKSK SKVDEDDFLD DDDDMELLKS KTEAETDRIS NLKIQIQKLT TKNDEDEIQS
VKIVDNQDLA FRSVKIDQEM NLRGKSDDED FQNDSEYSIL ERKKNFQISA NLKNVEKPST
AEQADKTQWP HLSYDFLQLE KIKDRQGNRM FLNYQNKEIN PDYDPSTLFV PQNFLNEQTP
AHRQWWEMKS LHFDTILFFK MGKFYEFFHM DAVVCTKELK ILFMRGEIAH AGFPEKSYKQ
YADALIQKGY KVARVEQTET PEMMAERCKT IKKASKFDKV VKREICRIST IGTRYLSDID
SDTILSYNSY LMSIVCRTNQ TDDNQSLEYG VCFVDVSVGK FFLSQFKDDR FNSKLRIVLS
HFCPVEIILE RSSKMKKLIQ SICPMARLQE AKNFWSSSQS LKYVYEKDLW SNVPDKFRQS
ILDPKDVIQQ TAREEYCFAT VALGAVLSYL DDSLILDDIT TMKQFEIYEP PEYDYKVSKL
PNHMILDSMT MKNLEIFNSS SNISNNRSFT LFKLIDNCGT AFGKRQLHSW LCQPICFLRE
SLELRQEAVR ELNENENFYS HLKQWQTLMK KLPDLDRLLT QIHSQSLLKS SKNHPDSRAI
MFESDVYQKR KIKTFLDVLA GFEKILTIIR QLRECVNDNR SRLLKQLILY SDEGGSFPRI
DDRLKFFQNS FNHEKVLREG NFIPDKGVDE EYDKAIEEIQ SAERQLNEYL NQQQLKFKTR
ITYCHANKNR YMMEVPDSVA SKLSRSEEKY ELKSARKGFK RFHTDALIEL VGVLEEAEQK
RTMILGDIFR RLLAKFDSDF EQWQKAISLA AQIDALMSLA HTRQIFESNG SKSCLPEIVW
DRTDPFIRIK ELRNAFLVIN NNQTSNDLEL CGETLILTGP NMSGKTTLMR SVGLVTILAQ
IGAYVPASEC TLTPVDRIFT RIGAYDLVLE NQSSFMVELS EAMAIIKYAT PFSLALIDEL
GSGTSTFDGT AIASAIITNL TEKNHCRIIF STHYHSILDE VDGKSNIKLG YMSYMIENEN
DQDPTEENII FLYRLQSGIC NKSYGFNVSK LAGIPQHIIR RAYNYAEKFE LELKIKSILN
WFRERKNHDQ CLNANADEKQ RMGIELQNAI QKFNEIEQNN PI
//
