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Database: UniProt
Entry: A0A132MLS7_9ACTN
LinkDB: A0A132MLS7_9ACTN
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ID   A0A132MLS7_9ACTN        Unreviewed;       488 AA.
AC   A0A132MLS7;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=LI90_1 {ECO:0000313|EMBL:KWW98381.1}, TH66_20800
GN   {ECO:0000313|EMBL:KWW97859.1}, TR74_22400
GN   {ECO:0000313|EMBL:KWX06308.1};
OS   Streptomyces thermoautotrophicus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1469144 {ECO:0000313|EMBL:KWW98381.1, ECO:0000313|Proteomes:UP000070188};
RN   [1] {ECO:0000313|EMBL:KWW97859.1, ECO:0000313|Proteomes:UP000070598, ECO:0000313|Proteomes:UP000070659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UBT1 {ECO:0000313|Proteomes:UP000070598,
RC   ECO:0000313|Proteomes:UP000070659};
RA   MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C.,
RA   Murray J.W., Prell J.;
RT   "Physiological reanalysis, assessment of diazotrophy, and genome
RT   sequences of multiple isolates of Streptomyces thermoautotrophicus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KWW98381.1, ECO:0000313|Proteomes:UP000070188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H1 {ECO:0000313|EMBL:KWW98381.1,
RC   ECO:0000313|Proteomes:UP000070188};
RA   MacKellar D.C., Lieber L., Norman J., Bolger A., Tobin C.,
RA   Murray J.W., Woodward J., Friesen M., Prell J.;
RT   "Physiological reanalysis, assessment of diazotrophy, and genome
RT   sequences of multiple isolates of Streptomyces thermoautotrophicus.";
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KWW98381.1}.
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DR   EMBL; JYIJ01000019; KWW97859.1; -; Genomic_DNA.
DR   EMBL; LAXD01000001; KWW98381.1; -; Genomic_DNA.
DR   EMBL; JYIK01001107; KWX06308.1; -; Genomic_DNA.
DR   RefSeq; WP_066883080.1; NZ_LAXD01000001.1.
DR   EnsemblBacteria; KWW97859; KWW97859; TH66_20800.
DR   EnsemblBacteria; KWW98381; KWW98381; LI90_1.
DR   EnsemblBacteria; KWX06308; KWX06308; TR74_22400.
DR   PATRIC; fig|1469144.10.peg.72; -.
DR   Proteomes; UP000070188; Unassembled WGS sequence.
DR   Proteomes; UP000070598; Unassembled WGS sequence.
DR   Proteomes; UP000070659; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070188,
KW   ECO:0000313|Proteomes:UP000070598, ECO:0000313|Proteomes:UP000070659};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070188}.
FT   DOMAIN      178    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      391    460       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     186    193       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   488 AA;  54204 MW;  17FBE4FDF588FC23 CRC64;
     MADETRDLAA VWARSLEQLA EGSVAPQHRA FIQLTRPLAL VGDTALLAAP NDFAKDILET
     RLRPLITDAL SRELGRDIRI AVTVEPEPPR EPERGEPLTP PADTALVSQD VTRPGTGPQP
     IVPPYSGDAT GAGGTETPDD DEGARLNPKY IFDTFVIGSS NRFAHAAAVA VAEAPAKAYN
     PLFIYGESGL GKTHLLHAIG HYARSLYQGA RVRYVSSEEF TNEFINSIRD GKADGFRRRY
     RDVDILLVDD IQFLENKEQT QEEFFHTFNT LHNASKQIVI SSDRPPKQLV TLEDRLRNRF
     EWGLITDVQP PELETRIAIL RKKAAQEGLN APPEVLEYIA SKISRNIREL EGALIRVTAF
     ASLNRQSVDL QLAEIVLKDL IPESEGGSEI TPSLIIAQTA AYFGLSMEDL CGTSRSRVLV
     TARQIAMYLC RELTDMSLPK IGQQFGGRDH TTVMHADRKI RSLMAERRSI YNQVTELTNR
     IKSQARQA
//
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