ID A0A132PC64_9MYCO Unreviewed; 980 AA.
AC A0A132PC64;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:KWX19923.1};
GN ORFNames=AFM11_33045 {ECO:0000313|EMBL:KWX19923.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX19923.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX19923.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX19923.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX19923.1}.
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DR EMBL; LGTW01000033; KWX19923.1; -; Genomic_DNA.
DR RefSeq; WP_067858459.1; NZ_LGTW01000033.1.
DR AlphaFoldDB; A0A132PC64; -.
DR STRING; 59750.AWC31_17180; -.
DR PATRIC; fig|59750.3.peg.4941; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 771..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 229..356
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 961..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 106562 MW; 5E49D1B2C9E33493 CRC64;
MSTDNTRPPF VAKTIRRTSP IIVVAWLALI VFTTLSSVNW DWRSAIPALE HVAERNSVSL
MPADAPSTKA MLRMGQAFEE SDSDSSAMIV LEGDTALGDN ARAYYAGLVD ALRKDSEHVT
HVQDLWGDRL TSSSVQSPDG KAAYVQINLV GNQGTPSGDE SVAAVRDLVD RSGPPEGVKV
FVTGAAPLAS DMQHSGNESI VKITIATLVI IFTMLLIVYR SVITVILLLV MVGFEVGAAR
GVVAFLGAHE VFLLSTFAVN MLVFLAIAAG TDYGIFFFGR YQEERQAGQD REAAYYRTYQ
STVPVVLASG LTIAGAIFCL SFTRLPYFQT MGIPCAIGML VAVAAAVTLV PAGIVLASSI
GLLDPKRRLK SRRWRGIGTA IARWPAPILA ASLAAAFVGL FALPGYETSY NDRAYISADI
PANQGFLAAE RHFSQARLTP DILMIETERD LRNPTDFITL NKLAKAVFKV QGISRVQGIT
RPEGSPIAKT SIPFLISLQS AAQVQSRKLQ DERNKDMLKQ AQDMGVMIQL MENQLNLMKQ
LYGITHRMLG TTKEIEDISL QLLEHIQAFD DFFKPIRNYL YWEPHCYSIP LCWALRSIYD
TLDGMDVLTE KLSKLVNDME QLDAIVPQLI AEFPKAIAVM KTIQTMTLKN YSTMSGMATQ
LEDQTAQVSA MGQAFDAAKN DDSFFLPPEV FDNPDFKRAM ASFISPDGKS ARFIISHNGD
PATPEGIARI EKVRLAAEEA LKGTPLSGAK IYLAGTASTA KDWRDGSTTD LLIAGIAAIC
LVFVIMLIIT RSLVAALVIV GTVVLSLGAS FGLAVLVWQY ILGIHLHWMV LAMSVIILLA
VGSDYNLLLV SRLKEELGAG IQTGIIRAMG GTGKVVTTAG LVFAATMASM AVSDLQIIGQ
IGTTIGLGLL FDTMIVRSFM TPSIAALLGR WFWWPQRVRP RPASVLLRPY GPRPLVRALL
GTDQRPDDDD APTAEIPRQS
//
