ID A0A132PC86_9MYCO Unreviewed; 382 AA.
AC A0A132PC86;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KWX19951.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:KWX19951.1};
GN ORFNames=AFM11_33200 {ECO:0000313|EMBL:KWX19951.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX19951.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX19951.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX19951.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX19951.1}.
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DR EMBL; LGTW01000033; KWX19951.1; -; Genomic_DNA.
DR RefSeq; WP_067858552.1; NZ_LGTW01000033.1.
DR AlphaFoldDB; A0A132PC86; -.
DR STRING; 59750.AWC31_17025; -.
DR PATRIC; fig|59750.3.peg.4972; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KWX19951.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KWX19951.1}.
FT DOMAIN 5..252
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 260..381
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 338
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 368
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 382 AA; 40618 MW; 040F89F86B680E1C CRC64;
MPEAYIIDAV RSPVGKKNGS LAQVHPIDLG VHVFRSIFDR NDVDPGAVDD VIVGCVDAIG
GQAGNIGRNA WLAAGYPEEV PGVTVDRQCG SSQQAISFGA QAILSGTADI ILAGGMQNMS
WVPISSAMIV GKELGFSTPI AESENWRHRY GDQEISQFRG SELIAERWDI SREEMEQFAL
ASHQRAFAAI RAGHFDNEIV PVGDFGVDEG PRETTLEKMA SLQPLVEGGR LTAALASQIS
DGSSAVLLAS EQAVKEHNLT PRARIHHISA RGADPVMMLT GPIPATQYAL QKTGLTIEDI
DTVEINEAFA PVVLAWMKDL KADPEKVNPS GGAIALGHPL GATGAKLFAT MLNTLERTGG
RYGLQTMCEG GGTANVTIIE RL
//
