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Database: UniProt
Entry: A0A132PMV2_9MYCO
LinkDB: A0A132PMV2_9MYCO
Original site: A0A132PMV2_9MYCO 
ID   A0A132PMV2_9MYCO        Unreviewed;       499 AA.
AC   A0A132PMV2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   05-JUL-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AFM11_14765 {ECO:0000313|EMBL:KWX23527.1};
OS   Mycobacterium wolinskyi.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX23527.1, ECO:0000313|Proteomes:UP000070612};
RN   [1] {ECO:0000313|EMBL:KWX23527.1, ECO:0000313|Proteomes:UP000070612}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC_01 {ECO:0000313|EMBL:KWX23527.1,
RC   ECO:0000313|Proteomes:UP000070612};
RA   de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA   Limbago B.M., Noble-Wang J.;
RT   "A draft genome sequence of Mycobacterium wolinskyi.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KWX23527.1}.
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DR   EMBL; LGTW01000008; KWX23527.1; -; Genomic_DNA.
DR   RefSeq; WP_067849940.1; NZ_LGTW01000008.1.
DR   EnsemblBacteria; KWX23527; KWX23527; AFM11_14765.
DR   PATRIC; fig|59750.3.peg.7063; -.
DR   Proteomes; UP000070612; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070612};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070612}.
FT   DOMAIN      192    320       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      404    472       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     200    207       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   499 AA;  56006 MW;  AE462BE1A26007C5 CRC64;
     MTADPDPPFV AVWNSVVAEL NGDHEGGRQG DSSLPALTPQ QRAWLKLVKP LVIAEGFALL
     SVPTPFVQNE IERHLREPIV TALSRKLGQR VELGVRIATP PDEPDDPGPD SAHDPAPLSV
     DTDEIDDDRE AKVNAEESWP TYFSSPQQDP AAADGNAVNL NRRYTFDTFV IGASNRFAHA
     ATLAIAEAPA RAYNPLFIWG ESGLGKTHLL HAAGNYAQRL FPGMRVKYVS TEEFTNDFIN
     SLRDDRKASF KRSYRDIDIL LVDDIQFIEG KEGIQEEFFH TFNTLHNANK QIVISSDRPP
     KQLATLEDRL RTRFEWGLIT DVQPPELETR IAILRKKAQM DRLDVPDDVL ELIASSIERN
     IRELEGALIR VTAFASLNKT RIDKSLAEVV LRDLIADATT MQISTAAIMA ATAEYFETTV
     EELRGPGKTR ALAQSRQIAM YLCRELTDLS LPKIGQAFGR DHTTVMYAEK KIRGEMAERR
     EVFDHVKELT TRIRQRAKR
//
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