ID A0A132PMV2_9MYCO Unreviewed; 499 AA.
AC A0A132PMV2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 28-MAR-2018, entry version 16.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01020005};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN ORFNames=AFM11_14765 {ECO:0000313|EMBL:KWX23527.1};
OS Mycobacterium wolinskyi.
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX23527.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX23527.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX23527.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation
CC of chromosomal replication. Binds to the origin of replication; it
CC binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC ECO:0000256|SAAS:SAAS00747961}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC ECO:0000256|SAAS:SAAS00555179}.
CC -!- CAUTION: The sequence shown here is derived from an
CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC preliminary data. {ECO:0000313|EMBL:KWX23527.1}.
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DR EMBL; LGTW01000008; KWX23527.1; -; Genomic_DNA.
DR RefSeq; WP_067849940.1; NZ_LGTW01000008.1.
DR EnsemblBacteria; KWX23527; KWX23527; AFM11_14765.
DR PATRIC; fig|59750.3.peg.7063; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF48295; SSF48295; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00362; DnaA; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW Complete proteome {ECO:0000313|Proteomes:UP000070612};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|SAAS:SAAS00747973};
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00748008};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612}.
FT DOMAIN 192 320 AAA. {ECO:0000259|SMART:SM00382}.
FT DOMAIN 404 472 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT NP_BIND 200 207 ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ SEQUENCE 499 AA; 56006 MW; AE462BE1A26007C5 CRC64;
MTADPDPPFV AVWNSVVAEL NGDHEGGRQG DSSLPALTPQ QRAWLKLVKP LVIAEGFALL
SVPTPFVQNE IERHLREPIV TALSRKLGQR VELGVRIATP PDEPDDPGPD SAHDPAPLSV
DTDEIDDDRE AKVNAEESWP TYFSSPQQDP AAADGNAVNL NRRYTFDTFV IGASNRFAHA
ATLAIAEAPA RAYNPLFIWG ESGLGKTHLL HAAGNYAQRL FPGMRVKYVS TEEFTNDFIN
SLRDDRKASF KRSYRDIDIL LVDDIQFIEG KEGIQEEFFH TFNTLHNANK QIVISSDRPP
KQLATLEDRL RTRFEWGLIT DVQPPELETR IAILRKKAQM DRLDVPDDVL ELIASSIERN
IRELEGALIR VTAFASLNKT RIDKSLAEVV LRDLIADATT MQISTAAIMA ATAEYFETTV
EELRGPGKTR ALAQSRQIAM YLCRELTDLS LPKIGQAFGR DHTTVMYAEK KIRGEMAERR
EVFDHVKELT TRIRQRAKR
//
