ID A0A132PPR2_9MYCO Unreviewed; 952 AA.
AC A0A132PPR2;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:KWX24329.1};
GN ORFNames=AFM11_10130 {ECO:0000313|EMBL:KWX24329.1};
OS Mycolicibacterium wolinskyi.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=59750 {ECO:0000313|EMBL:KWX24329.1, ECO:0000313|Proteomes:UP000070612};
RN [1] {ECO:0000313|EMBL:KWX24329.1, ECO:0000313|Proteomes:UP000070612}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC_01 {ECO:0000313|EMBL:KWX24329.1,
RC ECO:0000313|Proteomes:UP000070612};
RA de Man T.J., Perry K.A., Coulliette A.D., Jensen B., Toney N.C.,
RA Limbago B.M., Noble-Wang J.;
RT "A draft genome sequence of Mycobacterium wolinskyi.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX24329.1}.
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DR EMBL; LGTW01000005; KWX24329.1; -; Genomic_DNA.
DR RefSeq; WP_067847471.1; NZ_LGTW01000005.1.
DR AlphaFoldDB; A0A132PPR2; -.
DR PATRIC; fig|59750.3.peg.6062; -.
DR Proteomes; UP000070612; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000070612};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 764..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 790..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..381
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 601..936
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 952 AA; 103358 MW; AF98CB215B0EC4FE CRC64;
MTGQHHSSSH SGIARVIRVA AIPIILVWVA IVVVLNALLP QLEVVGHENS VSLSPQDAPA
LVAMKKIGER FNQFDSDTIA MVVLEGDEPL GDEAHRYYDE LVRTLEADTE HVQHVQNYWG
DLITAAGSQS TDGKAAYVQV NLAGNQGETL ANESVAAVRQ IIEDSNPPAG VKAYVTGQGP
LTTDMNEAGD KSMITITFVT IAVIAVMLLV VYRSIATTLL MLIIVLLEMS AARGVVAAIG
HAHLLGLSTF AVSLLTSLAI AAGTDYAIFL VGRYQEARQK GQDREEAYYT AFHGVGHVIL
GSGLTVAGAM LCLHFTRLNY FSSMGIPSAI GMGVVVLASL TLAPAVLVVG SRLGLLDAKR
KIRSRGWRKV GTSVVRWPVP ILTAAIAIAL VGLLALPGYK TSYNERLYIP QDLPSNVGYA
AAERHFTAAR MNPDLLLVDA GRDLRNPADM IVLDKIAREL IRVPGVARVQ SITRPLGRPI
AHSSVPFQVS MQSVSMTENL QFLRERMGDM LTMTDDLGRM ITIMENMLGM MTRMTEITHE
LTATMTEMEA NTREMRDHIA NFDDFMRPMR NYFYWEPHCY DIPVCNAMRS VFDGLDGIND
MSDSITESMK NMTEMDQLMP QLVAQLPPMI AISKSMQGTM KTMYSTFNGL IDQISKMTDT
ASVMGQAFDD ARNDDSFYLP PEAFDNPDFK RGLELMVSPD GQAAQFIITH DVDPATTEGI
SHVDPLLQAA REAIKTTPLA DAKIYLGGTA ATYKDIQVGA QWDLLISAVG AITLIFMVML
LITRALIASL VIVGTVILSL AASFGLSVLV WQYLLGIDLH WMTLAFSVIV LLAVGSDYNL
LVVSRMKEEI GAGINTGIIR AMGATGGVVT AAGLVFAFTM ASMATSDLIA IGQGGTTIGL
GLLFDTLVVR SLMTPSIAAI LGRWFWWPLR VRQRPARHRR DDTAPIPVVS PT
//
