ID A0A132SCT5_9MYCO Unreviewed; 493 AA.
AC A0A132SCT5;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ASJ79_12975 {ECO:0000313|EMBL:KWX56953.1};
OS Mycobacterium sp. NAZ190054.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1747766 {ECO:0000313|EMBL:KWX56953.1, ECO:0000313|Proteomes:UP000070146};
RN [1] {ECO:0000313|EMBL:KWX56953.1, ECO:0000313|Proteomes:UP000070146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAZ190054 {ECO:0000313|EMBL:KWX56953.1,
RC ECO:0000313|Proteomes:UP000070146};
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KWX56953.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMVQ01000575; KWX56953.1; -; Genomic_DNA.
DR RefSeq; WP_067962863.1; NZ_LMVQ01000575.1.
DR AlphaFoldDB; A0A132SCT5; -.
DR OrthoDB; 1931120at2; -.
DR Proteomes; UP000070146; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF48; TWO-COMPONENT SENSOR HISTIDINE KINASE-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KWX56953.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070146};
KW Transferase {ECO:0000313|EMBL:KWX56953.1}.
FT DOMAIN 15..120
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 298..478
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 493 AA; 54211 MW; AC80B69973D05AFA CRC64;
MGEKCLPDEL RTLFLFEALS DEQLATLCAN GHIETFEPGP IHTEGDPATC FYVLIDGELV
MSKRSGGVDI ETNRTSQRGV YCGAWSAYIP GEEHVYQASV RVTRPSRFFV LDADAFAEFM
QKEFPMAVHL LEGHMVGGLR QRQILGQREK LLALGQLSAG LTHQLNNPAG ATARAVADLR
EGVGKMRHKL AMLADGEFTP AALKVLVSIQ DEVAEYVAKS KSQELTALEA SDREDQIGDW
LEDHGISAAW DYAPTFVEAG LDVDWLERVE ASVDDVDCSA TLPGAIGWLK YTIDNELLMN
QIAEASKRIS ALLAGAKQYS QMDRAEYQKI NVHELLFSTV KTIFGDKLGK DKVNVVWDKD
KTLPELSCYP GDLNQVWTNL IDNAIQAMDG HGTLTIRTRR QSSDAGIVVE ICDDGPGIPE
DIVDRIFTPF FTTKPFGEGT GLGLDLAWRI VVEKHHGHLA VESRPGDTRF IVSLPWQAPA
PENPTKVGAT SDD
//
