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Database: UniProt
Entry: A0A133XSM4_9BACT
LinkDB: A0A133XSM4_9BACT
Original site: A0A133XSM4_9BACT 
ID   A0A133XSM4_9BACT        Unreviewed;       475 AA.
AC   A0A133XSM4;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   05-JUL-2017, entry version 11.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1869_01373 {ECO:0000313|EMBL:KXB33938.1};
OS   Bacteroidales bacterium KA00251.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales.
OX   NCBI_TaxID=1497953 {ECO:0000313|EMBL:KXB33938.1, ECO:0000313|Proteomes:UP000070662};
RN   [1] {ECO:0000313|EMBL:KXB33938.1, ECO:0000313|Proteomes:UP000070662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA00251 {ECO:0000313|EMBL:KXB33938.1,
RC   ECO:0000313|Proteomes:UP000070662};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KXB33938.1}.
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DR   EMBL; LSCS01000092; KXB33938.1; -; Genomic_DNA.
DR   RefSeq; WP_066041904.1; NZ_KQ959277.1.
DR   EnsemblBacteria; KXB33938; KXB33938; HMPREF1869_01373.
DR   PATRIC; fig|1497953.3.peg.1357; -.
DR   Proteomes; UP000070662; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070662};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070662}.
FT   DOMAIN      172    306       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      383    452       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     180    187       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   475 AA;  53640 MW;  062D09D4A3F26E83 CRC64;
     MTNYNTSSAH KENFTPIHEQ GVEEVWSRCL SYFESVLDKR ELETWFRPIQ PVKLESSTLT
     IRVPTVYFLE MLEANYSKVF SHILSELLGS EASLCCEALV DSSAKEFAKG AVKSVSGDIK
     GSPSEFAQEA PRVYFDSHLI KNYTFDTFVG GISNNVPRTF AKHICEHPGT PVINPFFIYG
     APGVGKTHLL NAIGHQLLKN EPSLRVLYVS TDNFVQQFTS AACNHKTADF TKYYRQVDVL
     LIDDIQSLIG KNKTQEAFFQ IFNHLYLLGK QLVLTCDKPP VELRGMEERL ISRIAGSCIA
     QIERPDEGLR RSILDRKLNE EGLSLKEDVK ELIVKSVSSN LRELEGTLTS LMLHSIVSQR
     PIDLSLAKEI IGRTVKIEVK EVSMERIMEL TCELLRVTAE EVRGKSRKQE FVMARQLVMY
     LTKEYTDEAY AAIGVMLGDR SHSTVVHGCN TIKSQLLVSP MVRDYVKTLE ERLGV
//
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