ID A0A133XXL3_9ACTN Unreviewed; 673 AA.
AC A0A133XXL3;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN ORFNames=HMPREF3192_00101 {ECO:0000313|EMBL:KXB35695.1};
OS Atopobium deltae.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Atopobium.
OX NCBI_TaxID=1393034 {ECO:0000313|EMBL:KXB35695.1, ECO:0000313|Proteomes:UP000070675};
RN [1] {ECO:0000313|Proteomes:UP000070675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DNF00019 {ECO:0000313|Proteomes:UP000070675};
RA Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC ChEBI:CHEBI:456215; EC=6.1.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001234};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC MetG type 1 subfamily. {ECO:0000256|ARBA:ARBA00008258}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXB35695.1}.
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DR EMBL; LSCR01000001; KXB35695.1; -; Genomic_DNA.
DR RefSeq; WP_066304377.1; NZ_KQ959483.1.
DR AlphaFoldDB; A0A133XXL3; -.
DR STRING; 1393034.HMPREF3192_00101; -.
DR PATRIC; fig|1393034.3.peg.96; -.
DR OrthoDB; 9810191at2; -.
DR Proteomes; UP000070675; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 2.20.28.20; Methionyl-tRNA synthetase, Zn-domain; 1.
DR InterPro; IPR023458; Met-tRNA_ligase_1.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR029038; MetRS_Zn.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR Pfam; PF09334; tRNA-synt_1g; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000070675}.
FT DOMAIN 16..254
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 311..468
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 673 AA; 76328 MW; 6911E69BF5C86833 CRC64;
MSVDMSKRPS FPKRAVITAG MPYGNKNLHF GHIGGVFVPA DFFARFLRDR IGASNVVFVS
GTDCYGSPIM EGYRKLKEQQ NYEGSILDYV QENHDAQKHA LNAYHISLDL YSGSGLEPAK
SFHNKMSQRV ITRLYERGYL HKLSTMQFYD PQAEQFLNGR QVMGRCPIRG CKSEKAYADE
CDLGHQFDPE ELIAPVSQLT GATPELRPVA NWYFDLPKFH ADLEKVMRDW DADPQVRSVV
TKTARESLAQ PCIYIQTRYR DEFEAIREQL PSHSLTEATQ NQSSFSVSFA DWEARDTARS
VLEEKSIRFR TGKTLLPFRI TGNIDWGIPA PELEGLRDLT VWCWPESLWA PISFTQTALA
CDTNGHFSSH DWSDWWRADD AAVYQFIGQD NIYFYCVVQP ALWNALAWDW FQDTPVANYH
ILFMNKKASS SGAIKPPMAE ELLENYTAEQ LRCHWLSLAL DQKAVSFAPK TYDISVSHVD
KKTGEEILVK DDPRVVDPAL KESAFLTNIF NRLARSCFYG AQNACGGMLP DATPSQEVLD
ECTSALLDFE QAASVFDAHT ALSIAEKFTR DANKRWDSAS KAGREDQALY VQALADAFAQ
LRCATLLMHP AAPDGCELIC QYLNFDPEQF FSWDNAFKTP QELAQLAGQN PAEHVLRTLR
ARFDFFSKHK TQK
//
