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Database: UniProt
Entry: A0A133Y742_9FIRM
LinkDB: A0A133Y742_9FIRM
Original site: A0A133Y742_9FIRM 
ID   A0A133Y742_9FIRM        Unreviewed;       520 AA.
AC   A0A133Y742;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1872_01338 {ECO:0000313|EMBL:KXB39016.1};
OS   Clostridiales bacterium KA00274.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales.
OX   NCBI_TaxID=1497955 {ECO:0000313|EMBL:KXB39016.1, ECO:0000313|Proteomes:UP000070080};
RN   [1] {ECO:0000313|EMBL:KXB39016.1, ECO:0000313|Proteomes:UP000070080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA00274 {ECO:0000313|EMBL:KXB39016.1,
RC   ECO:0000313|Proteomes:UP000070080};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KXB39016.1}.
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DR   EMBL; LSCV01000044; KXB39016.1; -; Genomic_DNA.
DR   RefSeq; WP_066714970.1; NZ_KQ959597.1.
DR   EnsemblBacteria; KXB39016; KXB39016; HMPREF1872_01338.
DR   PATRIC; fig|1497955.3.peg.1305; -.
DR   Proteomes; UP000070080; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070080};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070080}.
FT   DOMAIN      216    344       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      427    496       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     224    231       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   520 AA;  59498 MW;  4B91A9B0F2250E54 CRC64;
     MDMSDALNLD NEQAALAKTI WHNALKKIKS KVSTVLFVTW IEPLVPFYVD ENRLFLSTPD
     DFSYRYLVKY LPLFADVIAE SNSFRLEVKL VVGTEGIKQA LANLQPDSVT SSFDAAQTVI
     EQREANIEPE FVNEKVEPEV QVKPETFAAV QPKQTFIQPQ AIDEQPQAKI IVNPLYQQHF
     RKDYTFDNFI VGPNNTMAHA ACQAIANSYF TDGQKPYNPL FLYGGSGLGK THLLNAIGNS
     VLQHRPQTRI LYLQTEDFVN EFIATIRKQN YNVFRNKYRN CDLLLIDDIQ FIEGKEQMQE
     EFFYTFNTLY ENNAYIVITC DKHPRYLVTL EERLKTRFLS GLACDINPPN YETRMAILQA
     RAQALHEDID INIISYIAKN ISLNIRELEG ALNSVLAIKH LSGYINLTLA EKALEPIIKH
     NIAETITPDF IADVVATYYN IVKANLYSSC KESKYTYPRH VAMYLCRDLL NMTYASISKA
     FNRSDHTTTR NACLKIEKAL KNDLSLQKEI ASIKNSLHEH
//
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