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Database: UniProt
Entry: A0A133ZF60_9ACTN
LinkDB: A0A133ZF60_9ACTN
Original site: A0A133ZF60_9ACTN 
ID   A0A133ZF60_9ACTN        Unreviewed;       537 AA.
AC   A0A133ZF60;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF3190_00216 {ECO:0000313|EMBL:KXB54056.1};
OS   Coriobacteriales bacterium DNF00809.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   unclassified Coriobacteriales.
OX   NCBI_TaxID=1588753 {ECO:0000313|EMBL:KXB54056.1, ECO:0000313|Proteomes:UP000070490};
RN   [1] {ECO:0000313|EMBL:KXB54056.1, ECO:0000313|Proteomes:UP000070490}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00809 {ECO:0000313|EMBL:KXB54056.1,
RC   ECO:0000313|Proteomes:UP000070490};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KXB54056.1}.
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DR   EMBL; LSCX01000010; KXB54056.1; -; Genomic_DNA.
DR   RefSeq; WP_066779347.1; NZ_KQ959675.1.
DR   EnsemblBacteria; KXB54056; KXB54056; HMPREF3190_00216.
DR   PATRIC; fig|1588753.3.peg.205; -.
DR   Proteomes; UP000070490; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000070490};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070490}.
FT   DOMAIN      220    337       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      444    513       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     228    235       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   537 AA;  60846 MW;  48137DD14640D7DF CRC64;
     MDDFQLHEQW IQLCSTLRAQ HYISDGQFDA FFTQLEPKLI SAEEVILSTS NAFVKSWIEC
     NFVGYIASTL QKMYQCNPTI SIRLVEIQNA ATNTTVRNDN LGVHPQEVTG THETTEVCKT
     SGEHGDTKKP AGSQLTDNTS TVQTVSPEKK DTMQTNHILS MDSEIKTVST SSYDSASTPV
     PSEHTGIESA YTFENFVIGD SNRMAYSMSI EVAGNPGNRS LNPLFIYGKS GLGKTHLVRA
     IEDYIRVNLP HYTRLYKDAS SFLNEFIEAS MAHDKSKHTF RDFQNAYENV DVLLIDDVQL
     LQGKKQTLEI LFQIINTRIE KGMQIILSAD RAPKNIDIDE RYYSRFNSGG TVDIQPPEIE
     TKLSIIRNFI REYNRIAVPH TIVVPEEIEM YIAENSGSNI RELKSAITKV ISQIKIFGDD
     ALTLTTVRKL LENHFSGGAM RQLTVKAIQE VVEDYYKVKH DDLIGAKRSR DISYPRQIAI
     YLCREMLDIP FALVGESFGG RDHATIIYAV KSIEDRLEKS REVQEEIELI QKLIREK
//
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