ID   A0A134AHL2_9FIRM        Unreviewed;       449 AA.
AC   A0A134AHL2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=M18 family aminopeptidase {ECO:0000256|RuleBase:RU004387};
DE            EC=3.4.11.- {ECO:0000256|RuleBase:RU004387};
GN   ORFNames=HMPREF1863_00675 {ECO:0000313|EMBL:KXB67202.1};
OS   Peptoniphilus coxii.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Peptoniphilus.
OX   NCBI_TaxID=755172 {ECO:0000313|EMBL:KXB67202.1, ECO:0000313|Proteomes:UP000070442};
RN   [1] {ECO:0000313|Proteomes:UP000070442}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DNF00729 {ECO:0000313|Proteomes:UP000070442};
RA   Mitreva M., Pepin K.H., Mihindukulasuriya K.A., Fulton R., Fronick C.,
RA   O'Laughlin M., Miner T., Herter B., Rosa B.A., Cordes M., Tomlinson C.,
RA   Wollam A., Palsikar V.B., Mardis E.R., Wilson R.K.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU004387};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|ARBA:ARBA00008290, ECO:0000256|RuleBase:RU004386}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXB67202.1}.
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DR   EMBL; LSDG01000022; KXB67202.1; -; Genomic_DNA.
DR   RefSeq; WP_068367264.1; NZ_KQ960172.1.
DR   AlphaFoldDB; A0A134AHL2; -.
DR   PATRIC; fig|755172.3.peg.647; -.
DR   OrthoDB; 89722at2; -.
DR   Proteomes; UP000070442; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.250.10; Aminopeptidase i, Domain 2; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023358; Peptidase_M18_dom2.
DR   PANTHER; PTHR28570; ASPARTYL AMINOPEPTIDASE; 1.
DR   PANTHER; PTHR28570:SF2; M18 FAMILY AMINOPEPTIDASE 1-RELATED; 1.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; Aminopeptidase/glucanase lid domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438,
KW   ECO:0000256|RuleBase:RU004386};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070442};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   449 AA;  49258 MW;  3C7E00291010C62F CRC64;
     MEKIKSYWKL PDVQKDIAAF SEDYKTFLDR SKTERMAVAE IMRIAEKAGY NNLDDVEKLG
     RGDRVYVNNK GKSIMLFDIG ENPEKGMAII ASHIDSPRLD VKPNPLYEEN NVALLKTHYY
     GGIKKYQWTA IPLAIHGVMF RKDGTKVDVH VGSDPEDPIF TITDLLPHLS KSQNSKTLAE
     GIIGEKLNVL VGHKPGEVNV KEALLALLKE KYGIEEDDFT VSELEVVPAF SARDLGFDRS
     MIAGYGQDDR VCSYASLRAF VDGKDREKTC VAIFADKEEI GSVGNTSMSA NYFKNALGEV
     LHAMGNDDHL AINRALANSY VLSADVTAAM DPNYPEVMDK LNAAQLGEGV CMMKYTGARG
     KSGTSDANAE FLAALRKKFD EDGVIWQVGE MGKVDEGGGG TVAYILAETG AEVVDLGTAL
     FSMHAPYEVA SKADIYSTYK AYASFLTMK
//