ID A0A135L407_9BACI Unreviewed; 190 AA.
AC A0A135L407;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Transcription factor FapR {ECO:0000256|HAMAP-Rule:MF_01814};
DE AltName: Full=Fatty acid and phospholipid biosynthesis regulator {ECO:0000256|HAMAP-Rule:MF_01814};
GN Name=fapR {ECO:0000256|HAMAP-Rule:MF_01814};
GN ORFNames=U473_06455 {ECO:0000313|EMBL:KXG43696.1};
OS Tepidibacillus decaturensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Tepidibacillus.
OX NCBI_TaxID=1413211 {ECO:0000313|EMBL:KXG43696.1, ECO:0000313|Proteomes:UP000070352};
RN [1] {ECO:0000313|EMBL:KXG43696.1, ECO:0000313|Proteomes:UP000070352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z9 {ECO:0000313|EMBL:KXG43696.1,
RC ECO:0000313|Proteomes:UP000070352};
RA Dong Y., Chang J.Y., Sanford R., Fouke B.W.;
RT "Draft Genome for Tepidibacillus decaturensis nov. sp. Strain Z9, an
RT Anaerobic, Moderately Thermophilic and Heterotrophic Bacterium from Deep
RT Subsurface of the Illinois Basin, USA.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional factor involved in regulation of membrane
CC lipid biosynthesis by repressing genes involved in fatty acid and
CC phospholipid metabolism. {ECO:0000256|HAMAP-Rule:MF_01814}.
CC -!- SIMILARITY: Belongs to the FapR family. {ECO:0000256|HAMAP-
CC Rule:MF_01814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXG43696.1}.
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DR EMBL; LSKU01000001; KXG43696.1; -; Genomic_DNA.
DR RefSeq; WP_068724511.1; NZ_LSKU01000001.1.
DR AlphaFoldDB; A0A135L407; -.
DR STRING; 1413211.U473_06455; -.
DR OrthoDB; 1706183at2; -.
DR Proteomes; UP000070352; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd03440; hot_dog; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01814; Transcrip_fact_FapR; 1.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR006683; Thioestr_dom.
DR InterPro; IPR017275; Transcription_factor_FapR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03061; 4HBT; 1.
DR PIRSF; PIRSF037733; Transcription_factor_FapR; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Fatty acid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_01814};
KW Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_01814};
KW Reference proteome {ECO:0000313|Proteomes:UP000070352};
KW Repressor {ECO:0000256|HAMAP-Rule:MF_01814};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_01814};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_01814}.
FT DOMAIN 112..169
FT /note="Thioesterase"
FT /evidence="ECO:0000259|Pfam:PF03061"
SQ SEQUENCE 190 AA; 21933 MW; 5640FDB4B50221F2 CRC64;
MVIAIARIPK KKRQEELKNV VDENPLITDE ELAKKFQVSI QTIRLDRMEL GIPEQRERLK
SMAKENNDHV KSLQINEVIG EILDLQLDQY GISMMEIQED QVFNKTGIAR GHYIFAQANS
LAVALINEEI ALTAKAEIRF IRPVYLNERL VAKAKVIDQH LDRSEIEVET FVRNEIVFKG
KFTVYRSKGL
//
