ID A0A135LTK6_PENPA Unreviewed; 1111 AA.
AC A0A135LTK6;
DT 06-JUL-2016, integrated into UniProtKB/TrEMBL.
DT 06-JUL-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Guanine-nucleotide dissociation stimulator CDC25 {ECO:0000313|EMBL:KXG52259.1};
GN ORFNames=PGRI_085430 {ECO:0000313|EMBL:KXG52259.1};
OS Penicillium patulum (Penicillium griseofulvum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=5078 {ECO:0000313|EMBL:KXG52259.1, ECO:0000313|Proteomes:UP000070168};
RN [1] {ECO:0000313|EMBL:KXG52259.1, ECO:0000313|Proteomes:UP000070168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG3 {ECO:0000313|EMBL:KXG52259.1,
RC ECO:0000313|Proteomes:UP000070168};
RX PubMed=26729047; DOI=10.1186/s12864-015-2347-x;
RA Banani H., Marcet-Houben M., Ballester A.R., Abbruscato P.,
RA Gonzalez-Candelas L., Gabaldon T., Spadaro D.;
RT "Genome sequencing and secondary metabolism of the postharvest pathogen
RT Penicillium griseofulvum.";
RL BMC Genomics 17:19-19(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXG52259.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LHQR01000026; KXG52259.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A135LTK6; -.
DR STRING; 5078.A0A135LTK6; -.
DR OMA; EEVWERD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000070168; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000070168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..76
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 643..763
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 823..1066
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 228..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1111 AA; 124016 MW; F8C4D1E244742A2B CRC64;
MDQFEAPRPV FHNYLRAFYP FHPAGNVSPS TVTLPLDQGD IILVHSVHTN GWADGTLLDS
GNRGWLPTNY CEAYDQLPMR PLLKALTDFW DIIRGGCGSS LKDFGNQDLM RGPIAGVRFL
LEKSECLTRE SPLIRRFDGL RRIRKALLSD LSSLVKTAKK FQEVANGVPS EDEVETILDE
MLLKAFKIVT RGVRFLDVWN EEVGLSRTIA ELDGPGESLS QYNMPLTPAS ESFSLGDNDV
PDRSESRMLE SRLESRQMSH SRMDMSRSSM RTEIVDHRPA SVATKRVSVS HRMSVSGPST
TLGAQNLASE RLGTTYDAFL GVLGSFIGLH MQSRSSTELV VTTQQAVQSC RQLLNVVEVV
CEHDTHRSVF LEQARETMCE KLSELVHAAR DVFRPAQLPD DDLVFMPDEG KRLVDAATDC
VRAAGNCLAK ARLVLEQIGD LELDPEHYEE RGQDLSGIDS PQEQPETPVE QERQELSLRL
PPPPLQIPST TYSPPTPALT DATTPSSFQS HITNSPANIT ALSSLHSSAI LPTHMENNSS
FESVNSSYRE SHPKSDVSES FGRGVTSNGS SFTYNSYARD SEMSGLSQTS TRATSPDIGG
SFQGSFTVHS LKESLSYSTL AEENEETEAN ILEKTFAHEL IYKEGSVMGG SLRALIEKLT
AHQSTPDAMF VSTFYLTFRL FATPLEFAGA LAERFEYIGD TPHASGPVRL RVYNIFKGWL
ESHWRHDRDN TALDFIVNFA NTRLVVDLPT AGKRLLDLAS KVSAVGGPLV PRLVSSMGKT
NTSIAQYIHP DTPLPPPILG KKEHNLLKQW KNGEASITIL DFDPLELARQ LTIKESRIFC
SILPEELLDT EWTRKSGSLA VNVRAMSTLS TDLAHLVADS ILYLEEPKKR AATIKHWVKI
ANKCLELNNY DSLMAIICSL NLSMISRLKK TWDIVSQKTK TALEQLRSIV DVSRNYAVLR
QRLQNHVPPC LPFVGTYLTD LTFVDHGNQS LRTLSTDDSE MAVINFDKHM KTARIISELQ
RFQIPYRLTE VPELQAWMQN ELVRVRSNGE TTAQTFYRRS LVLEPRETSR SATTLQSQPE
TNPSMLDNAK DKFDFLSWTN QSKVKPVTTH G
//
