ID   A0A135VQG0_9ARCH        Unreviewed;       668 AA.
AC   A0A135VQG0;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN   ORFNames=AM325_05200 {ECO:0000313|EMBL:KXH74916.1};
OS   Candidatus Thorarchaeota archaeon SMTZ1-45.
OC   Archaea; Asgard group; Candidatus Thorarchaeota.
OX   NCBI_TaxID=1706444 {ECO:0000313|EMBL:KXH74916.1, ECO:0000313|Proteomes:UP000070149};
RN   [1] {ECO:0000313|EMBL:KXH74916.1, ECO:0000313|Proteomes:UP000070149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMTZ1-45 {ECO:0000313|EMBL:KXH74916.1};
RX   PubMed=26824177;
RA   Seitz K.W., Lazar C.S., Hinrichs K.U., Teske A.P., Baker B.J.;
RT   "Genomic reconstruction of a novel, deeply branched sediment archaeal
RT   phylum with pathways for acetogenesis and sulfur reduction.";
RL   ISME J. 0:0-0(2016).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M3 family.
CC       {ECO:0000256|ARBA:ARBA00006040}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXH74916.1}.
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DR   EMBL; LRSL01000019; KXH74916.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A135VQG0; -.
DR   STRING; 1706444.AM325_05200; -.
DR   Proteomes; UP000070149; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd06455; M3A_TOP; 1.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR   Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR024077; Neurolysin/TOP_dom2.
DR   InterPro; IPR024080; Neurolysin/TOP_N.
DR   InterPro; IPR045090; Pept_M3A_M3B.
DR   InterPro; IPR001567; Pept_M3A_M3B_dom.
DR   PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR   PANTHER; PTHR11804:SF84; SACCHAROLYSIN; 1.
DR   Pfam; PF01432; Peptidase_M3; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          219..664
FT                   /note="Peptidase M3A/M3B catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01432"
SQ   SEQUENCE   668 AA;  77606 MW;  0F12CF389C1C0400 CRC64;
     MVEPALGTMN EQGVIRKPDW TIDPEKMRAI ADEDIENAKK KLDEIAKTPK GEVHLQTLKD
     FEEVLGSGGD HLGYFIFIKH ISSNKAQRDM ADDIEKDVRK FINEIWGRKD LFEVFAELEP
     MMESLEPEDK MLLDHTLKEF RHRGAALDDD KRKEFLEVAN NISVLESEFA RVLNEITTTI
     PFTAEQLEGV PSPVYENLEK DGDNYLCPLD YPVYLPIVNY AKNPETRKKM MIISYQKGGK
     ENSERLSDIL ALRERQAKLL GYSNFAEYVI SRKMAKTPQR VIDFMNDLRK RLTPLSEKET
     QKLKKLKAKE LNKSPEDVTI ELWDIFYYHE MLMKMKYAVD QNEIKEYFPA HLVIQGVLDV
     YQKVLNLEFI EAEEPNTWHE DVREFKVIDK TNGHTLGVLY LDLYPRDGKF KHYAVWGFMD
     RRVRDGKVYL PMCSMVSNYE KPTKDKPSLL THSDVETFFH EFGHLMHMIC NQTKYARFGL
     DGVLPDFIET PSMMFENWAW KEEVLSNLSG HYKDTKKKLP SDLLRRMIDA KLLDIGTFQL
     RQVAYSLIDM VYHTEGADDT SAVFRKIFSE ITGYYMPDKV KMDAGFGHFA NSGYTAGYYS
     YLWSKAYAED IFTKFEENGY MDTKTGTEYR QKILAPGGSR NPDELVKSFL GREMNNDAFM
     KSLGLDNN
//