ID A0A136IV67_9PEZI Unreviewed; 726 AA.
AC A0A136IV67;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|RuleBase:RU367106};
GN ORFNames=Micbo1qcDRAFT_166219 {ECO:0000313|EMBL:KXJ88778.1};
OS Microdochium bolleyi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ88778.1, ECO:0000313|Proteomes:UP000070501};
RN [1] {ECO:0000313|Proteomes:UP000070501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG DOE Joint Genome Institute;
RA David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA Barry K., Grigoriev I.V.;
RT "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT beachgrass.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ethanolamine phosphate transferase involved in
CC glycosylphosphatidylinositol-anchor biosynthesis. Transfers
CC ethanolamine phosphate to the GPI second mannose.
CC {ECO:0000256|RuleBase:RU367106}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|RuleBase:RU367106}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU367106}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU367106}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|RuleBase:RU367106}.
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DR EMBL; KQ964257; KXJ88778.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A136IV67; -.
DR STRING; 196109.A0A136IV67; -.
DR InParanoid; A0A136IV67; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000070501; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU367106};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502,
KW ECO:0000256|RuleBase:RU367106};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367106};
KW Reference proteome {ECO:0000313|Proteomes:UP000070501};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367106};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367106};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367106}.
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 355..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 424..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 498..515
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 535..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 568..589
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 609..635
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 663..687
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT TRANSMEM 699..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367106"
FT DOMAIN 292..725
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 726 AA; 80182 MW; 2FFABD72D9ECD63C CRC64;
MKHKKPGKLV MHGDDTWLKL FPGIFDRADG TTSFFVSDFT EVDTNVTRHV PEELENDDWN
TMVLHYLGLD HIGHKTGPRG PNMVPKQHEM DGIVRQIYEG IQNKPHLEST LLVLIGDHGM
NDAGNHGASS AGETSPALVF VSPKLKTIAK QTKTPADFVE DFRYYSFVEQ SDLAPTLAAL
LGFPIPKNSL GSFITEFLPM WQGNDRMEIL LRNGRQIYDI LVATFGVPQA SEPLSEQFCS
TPASTAESLA CAWRTIQGTA DAAYEGSSFD PDWLNDITKW LNEAQSLMTS MASNYDVPRL
TLGSGISAAA VALSTISVVL SSTVSFTGLV PYTLITLLYG IMMFASSYVE EEQHFWYWAT
SIWFFFLTVK SLARKNGKPT RQTLITMGSA LLYLRVLRNW NQTGQKFAGE PDIVTIMLVP
HPSLLWLLVL SAYALVAWQL YHELRDVAPV ISGSLITGLV TSAVSFKLAF TREDAPELMT
GFASTLSNAF SGPTLVELAR AVFMGLGLAA IYPVYILLRR PAGSSPQSAM RTLHMLYTIF
AMTQSRATNI PLFIVYSGIS TLLVRLDLSV MEVATTSLLL QFASFFAMAG NNAISGIDLS
SAYNGVSGFD IGAVGVLTFL SNWAAPVWWS FWGVLRLLDC RHRGRDTALG AQQQHQQRPL
QQYIALQTAF VAASLAFVMA ACMALRTHLF IWTVFSPKYL YSMAWSLGQH LGINVLFGSL
LYWLGH
//
