ID   A0A136IWU9_9PEZI        Unreviewed;       317 AA.
AC   A0A136IWU9;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Reductase-like protein {ECO:0000313|EMBL:KXJ89388.1};
GN   ORFNames=Micbo1qcDRAFT_137228 {ECO:0000313|EMBL:KXJ89388.1};
OS   Microdochium bolleyi.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX   NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ89388.1, ECO:0000313|Proteomes:UP000070501};
RN   [1] {ECO:0000313|Proteomes:UP000070501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG   DOE Joint Genome Institute;
RA   David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA   Barry K., Grigoriev I.V.;
RT   "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT   beachgrass.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KQ964255; KXJ89388.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A136IWU9; -.
DR   STRING; 196109.A0A136IWU9; -.
DR   InParanoid; A0A136IWU9; -.
DR   OrthoDB; 5305445at2759; -.
DR   Proteomes; UP000070501; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF504; GLYCEROL 2-DEHYDROGENASE (NADP(+))-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070501}.
FT   DOMAIN          17..282
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        50
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         110
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            79
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   317 AA;  34554 MW;  EECEF0FEBE06ADFE CRC64;
     MAPTSFKLNT GAQIPAVGLG TWQSGPGEVA NAVTYALKVG YKLIDTAYCY GNEDEVGKGI
     KDAIDAGYVK REDIFVVTKL WNTYATRAEV GLDKSLKSLG LEYVDLFLVH WPVGMNPDGN
     DDRFPKLPNG ERDITWDHDH VATWKQMEGL VKTGKTKAVG VSNYSKVYLE KLLAKAEIVP
     AVNQVENHPA LPQDDLVSFC KDKKIHIMAY SPLGSTGSPL FQNESVKKVA ERKGVSAGTV
     LLSYHVARGS TVLPKSVTES RIKSNLEIVD LDDEDFKTLG EITAGGKVER FVFPPFGINF
     GFPDKSEGKA MPNGVDA
//