ID   A0A136IXR8_9PEZI        Unreviewed;       368 AA.
AC   A0A136IXR8;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   SubName: Full=Ketopantoate reductase PanE/ApbA-domain-containing protein {ECO:0000313|EMBL:KXJ89704.1};
GN   ORFNames=Micbo1qcDRAFT_234972 {ECO:0000313|EMBL:KXJ89704.1};
OS   Microdochium bolleyi.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX   NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ89704.1, ECO:0000313|Proteomes:UP000070501};
RN   [1] {ECO:0000313|Proteomes:UP000070501}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG   DOE Joint Genome Institute;
RA   David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA   Barry K., Grigoriev I.V.;
RT   "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT   beachgrass.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870}.
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DR   EMBL; KQ964254; KXJ89704.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A136IXR8; -.
DR   STRING; 196109.A0A136IXR8; -.
DR   InParanoid; A0A136IXR8; -.
DR   OrthoDB; 1548520at2759; -.
DR   Proteomes; UP000070501; Unassembled WGS sequence.
DR   GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:InterPro.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR003710; ApbA.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR00745; apbA_panE; 1.
DR   PANTHER; PTHR21708:SF42; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000070501}.
FT   DOMAIN          9..174
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          226..353
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   368 AA;  39898 MW;  D98E12B46CAF88C3 CRC64;
     MPEGQETHVL VVGAGAVGCF YASRLHHPSH NVHVSLTARS NYSAIAKSGV ILETHTFGNY
     TFQPHAVFPS VQAAVPGAAP QSQTPPPAAG WDYIIVTTKA LPDRTDDAAM IAPLVAPKSC
     VILIQNGVGV EEPYRQRFPT NPIISAVTIV SAEQIKQGTI RQNRWTRMSL GPYAHGLSKT
     SGGGPGDEND SAKLLDRATM AMNSLTEWWT KLGGIRDIEP HTEMELQTIR WHKLCINAAF
     NPTAVLSGGR GNADIVTDPE LREHIAGIMQ EVWDAAPKVL GRPFDGKEVA TPARIIKSNE
     RNKGSKPSML LDWEAGRPME LEVILGNPVR IARAAGVAMP RLQSVYAIMK SMQSVREERA
     EAAKKAKL
//