ID A0A136J270_9PEZI Unreviewed; 878 AA.
AC A0A136J270;
DT 11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT 11-MAY-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000313|EMBL:KXJ91331.1};
GN ORFNames=Micbo1qcDRAFT_134706 {ECO:0000313|EMBL:KXJ91331.1};
OS Microdochium bolleyi.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Microdochiaceae; Microdochium.
OX NCBI_TaxID=196109 {ECO:0000313|EMBL:KXJ91331.1, ECO:0000313|Proteomes:UP000070501};
RN [1] {ECO:0000313|Proteomes:UP000070501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J235TASD1 {ECO:0000313|Proteomes:UP000070501};
RG DOE Joint Genome Institute;
RA David A.S., May G., Haridas S., Lim J., Wang M., Labutti K., Lipzen A.,
RA Barry K., Grigoriev I.V.;
RT "Draft genome sequence of Microdochium bolleyi, a fungal endophyte of
RT beachgrass.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. Furin subfamily.
CC {ECO:0000256|ARBA:ARBA00005325}.
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DR EMBL; KQ964250; KXJ91331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A136J270; -.
DR STRING; 196109.A0A136J270; -.
DR InParanoid; A0A136J270; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000070501; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000070501};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..878
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007293394"
FT TRANSMEM 723..745
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 476..611
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT REGION 642..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..798
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..814
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 228
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 400
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 878 AA; 95010 MW; E02DEBF35B02E6D0 CRC64;
MRIATLVGLA AGGLAGLGSA NLQPRNYDAN DYYVLQLERG VDPIDVAARL DMRHEGPLGN
LAGHHMFSAA KRHDDIVARA IHDRRRRNSN YPDLIDRVPF WQKQQLRAPM TKRSVPQPAR
GAFPVEKRQE VNAEAAARQK SVMSELGISD PIFAEQWHLF NAVQVGHDVN VTDVWRAGVT
GHNSTVAIVD DGLDMYSNDL KSNYYAEGSY DFNDHKPEPK PTLSDDRHGT RCAGEIGAAK
NDVCGVGVAY DSKIAGIRIL SKLITESDEA LSLNYDFQHN QIYSCSWGPP DDGKSMEAPG
ILIKRAMLNG VQNGRKGKGS VYVFASGNGA VYEDNCNFDG YTNSIYSITV GAVDRKGLHP
YYSEHCSAQL VVTYSSGSGD AIHTTDVGEN TCSSSHGGTS AAAPLAAGIF ALALEVRPDL
SWRDMQYIAL QTAVVVDDSE EGLQTTTIGK KFSHTFGYGK LDTWSLVELA RTWKNVKPQA
WLFSPWIHIK QDIPQGDKGL TSVFTVTKEM LKDANLARLE HVTVTMNVEH HKRGDLSVDL
ISPSGLVSHI ATTRKLDLSE DGYNDWTFMS VVHWGEDGVG DWKIIVKDSQ VNDKSGKWID
WHLKLWGESI DADKATLLPM PTEEDDANHN ENIPVVTGIA HTTSLPSTPQ QTPSELPSVP
TDHPERPTKP GSGNQGEDKP SDTSSGSSSA SSSDSAAAET TTAASSWLPS FLPTFGVSSR
TQAWIYGAIS LIVVFCAGLG AWLYMQRRKR LSNTRDNYEF ELINEEEGEG LTGGRSGGGA
GAAGEKGRRR RGGELYDAFA DGSDDDMEMF SDGDDDEDDR RRAGGASASS AAAGSAATAV
GGASGSSKAR GVAQSDEEDD DSDEDSVNEK QGLRGGRR
//
