ID   A0A136M1B1_9BACT        Unreviewed;       609 AA.
AC   A0A136M1B1;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Sulfatase {ECO:0000313|EMBL:KXK27667.1};
GN   ORFNames=UZ12_BCD005001261 {ECO:0000313|EMBL:KXK27667.1};
OS   Bacteroidetes bacterium OLB12.
OC   Bacteria; Bacteroidota.
OX   NCBI_TaxID=1619897 {ECO:0000313|EMBL:KXK27667.1, ECO:0000313|Proteomes:UP000070129};
RN   [1] {ECO:0000313|EMBL:KXK27667.1, ECO:0000313|Proteomes:UP000070129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OLB12 {ECO:0000313|EMBL:KXK27667.1};
RA   Speth D.R., In T Zandt M., Guerrero Cruz S., Jetten M.S., Dutilh B.E.;
RT   "Genome based microbial ecology of anammox granules in a full-scale
RT   wastewater treatment system.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXK27667.1}.
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DR   EMBL; LNFR01000050; KXK27667.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A136M1B1; -.
DR   STRING; 1619897.UZ12_BCD005001261; -.
DR   PATRIC; fig|1619897.3.peg.1370; -.
DR   Proteomes; UP000070129; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.30.1120.80; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR012160; LtaS-like.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        54..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        80..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          264..533
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   ACT_SITE        312
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT   BINDING         272
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         312
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         427
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT   BINDING         481
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT   BINDING         482
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ   SEQUENCE   609 AA;  68921 MW;  5159C181890A0F4E CRC64;
     MRYRLRFFGL LALYWMAYFT LGRVLFLLYL LPQTNSLSLQ EITMPLLLGL RMDAAMTGYW
     LLLPGLLFVA SAFTSNRFTF YATGIITIML LLISTILVVT DLELYKHWGF RINSTPLMYL
     ESEAISSVNS GVLVGLILIF AALFSSFIFI YSRWLAPQLL TLPPIKKKHA LTWLVITTAL
     LIPIRSSFTV APLNTGVVYF HKTKSFPNHA GINPVWNFFR SVSKSKAVKY PGDFYQAGNL
     DAEFKSLMQT SETQFAIDST IHHPNVLLII LEGFTSKIIE PLGGLPNITP EFNALISEGM
     LFENFYASGD RTDKGLVSIL SAYVAQPRTS IIKFPEKTQH LPFLSKELER NGYATSFIYG
     GDVGFANMES YLTIAGFGSI TDEDEFDSNL NDSKWGVADH YVFTKMLREL NAAPNPFFKV
     MLSLSSHEPF EVPMETVIPG KDEGSMFLNA CYYTDRSLGE FIRQAKQQPW WKNTLVIVTA
     DHGHRFPDLL ELKDKSRFKI PMLWLGGVIT RPGTRIGTFA SQTDIANTLL AQLRIQPQSE
     FLFSKNILAR SVNPFAVYVF NNGFGYVSAT HESIYDFDIK NYVSQTGNEN ELTNGQIYMQ
     TLFNDYNRK
//