ID   A0A136NM34_9BACT        Unreviewed;       388 AA.
AC   A0A136NM34;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KXK47237.1};
GN   ORFNames=UZ10_BCD003000540 {ECO:0000313|EMBL:KXK47237.1};
OS   Bacteroidetes bacterium OLB10.
OC   Bacteria; Bacteroidota.
OX   NCBI_TaxID=1617421 {ECO:0000313|EMBL:KXK47237.1, ECO:0000313|Proteomes:UP000070480};
RN   [1] {ECO:0000313|EMBL:KXK47237.1, ECO:0000313|Proteomes:UP000070480}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OLB10 {ECO:0000313|EMBL:KXK47237.1};
RA   Speth D.R., In T Zandt M., Guerrero Cruz S., Jetten M.S., Dutilh B.E.;
RT   "Genome based microbial ecology of anammox granules in a full-scale
RT   wastewater treatment system.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009463}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXK47237.1}.
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DR   EMBL; LNBX01000021; KXK47237.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A136NM34; -.
DR   STRING; 1617421.UZ10_BCD003000540; -.
DR   PATRIC; fig|1617421.3.peg.564; -.
DR   Proteomes; UP000070480; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   3: Inferred from homology;
FT   DOMAIN          5..184
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          186..283
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          302..383
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   388 AA;  43167 MW;  D87975C7478AAE3B CRC64;
     MNQLKISVAG AGAMGAGIAQ VAATYGHQVT LYDSFQAALD KAKPAVRKSL DKAVEKNKLT
     AEKADAVMSA IRFTSDLNDI SGSDLFIEAI IEQIEAKQNL FYEVEKLVSD QCILATNTSS
     LPVIAIGSNC KNQERIIGLH FFNPPVLMQL VEVIPTFNTK AAITESCKTL MKNWGKVPVI
     AKDTPGFIVN RIARPYYGEA LRIYEEGIAG FETIDHAMKS VGGFKMGPFE LMDFIGNDIN
     YKVTETVFGQ MFYDPRYKPS ITQKRLFEGK LYGRKTGKGY YNYANPSEPK PSNDEALLQS
     IFDRIFAMLV NEAADALMMQ IASAEDIELA MTKGVNYPMG LLQWANTTGP EKVLATLQHL
     FEWYGEDRYR PSPLLKRVVA DKTLFKTR
//