ID A0A136PQ86_9ACTN Unreviewed; 415 AA.
AC A0A136PQ86;
DT 08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=[acyl-carrier-protein] S-malonyltransferase {ECO:0000256|ARBA:ARBA00013258};
DE EC=2.3.1.39 {ECO:0000256|ARBA:ARBA00013258};
GN ORFNames=AWW66_18425 {ECO:0000313|EMBL:KXK60534.1};
OS Micromonospora rosaria.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=47874 {ECO:0000313|EMBL:KXK60534.1, ECO:0000313|Proteomes:UP000070620};
RN [1] {ECO:0000313|EMBL:KXK60534.1, ECO:0000313|Proteomes:UP000070620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 803 {ECO:0000313|EMBL:KXK60534.1,
RC ECO:0000313|Proteomes:UP000070620};
RA Yang H., He X., Zhu D.;
RT "Whole genome sequence and analysis of Micromonospora rosaria DSM 803,
RT which can produce antibacterial substance rosamicin.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00000936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KXK60534.1}.
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DR EMBL; LRQV01000068; KXK60534.1; -; Genomic_DNA.
DR RefSeq; WP_067367791.1; NZ_LRQV01000068.1.
DR AlphaFoldDB; A0A136PQ86; -.
DR OrthoDB; 3543921at2; -.
DR Proteomes; UP000070620; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:KXK60534.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000070620};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KXK60534.1}.
FT DOMAIN 7..310
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
SQ SEQUENCE 415 AA; 44769 MW; 39BE23BC8C5D8FE1 CRC64;
MKDLVIVFPG QGSQFAGMGR KWFDEHESVR ERFAQASDIV GYSLADLCFT APPAEVTRTR
YAQVSLLVLS YSMYEVMTAG RKVPVSYLTG HSLGEITALL AAGALTFEDA VRLVKVRGEA
MEGCAADSGT GMIAAVRMPV ADVEKCVEDF NAAGHDVQVA NYNGELQTVL SGTLDDLKGI
TAHLEDRGGR AVKLNVAGAF HSTFMAGALP EYTKALSEVT IAEPAVPVYS NVTGEAYESA
EAIREALAVQ LTSPVRWSDI VAALVDRKAA VWIEVGPKQV LKKMLTGAVG SGEVYSLDEE
PDRVGAVLDH LVELKKREPG VVGLCLGAAA ATRNRNFDAD EYHNGVVVSY RKLQELSKLD
QESLSDQQKQ AAVELLLTIM RTKRVPEPEQ RDRIESILRR TGEVGLRTIA GALAT
//
