ID   A0A136PWY2_9ACTN        Unreviewed;       760 AA.
AC   A0A136PWY2;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Bi-functional transferase/deacetylase {ECO:0000313|EMBL:KXK62932.1};
GN   ORFNames=AWW66_05425 {ECO:0000313|EMBL:KXK62932.1};
OS   Micromonospora rosaria.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=47874 {ECO:0000313|EMBL:KXK62932.1, ECO:0000313|Proteomes:UP000070620};
RN   [1] {ECO:0000313|EMBL:KXK62932.1, ECO:0000313|Proteomes:UP000070620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 803 {ECO:0000313|EMBL:KXK62932.1,
RC   ECO:0000313|Proteomes:UP000070620};
RA   Yang H., He X., Zhu D.;
RT   "Whole genome sequence and analysis of Micromonospora rosaria DSM 803,
RT   which can produce antibacterial substance rosamicin.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KXK62932.1}.
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DR   EMBL; LRQV01000011; KXK62932.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A136PWY2; -.
DR   OrthoDB; 3864432at2; -.
DR   Proteomes; UP000070620; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06423; CESA_like; 1.
DR   Gene3D; 3.20.20.370; Glycoside hydrolase/deacetylase; 1.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR002509; NODB_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43630; POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE; 1.
DR   PANTHER; PTHR43630:SF1; POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE; 1.
DR   Pfam; PF13641; Glyco_tranf_2_3; 1.
DR   Pfam; PF01522; Polysacc_deac_1; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   PROSITE; PS51677; NODB; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070620};
KW   Transferase {ECO:0000313|EMBL:KXK62932.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        635..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        670..690
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        711..731
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          110..297
FT                   /note="NodB homology"
FT                   /evidence="ECO:0000259|PROSITE:PS51677"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          740..760
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   760 AA;  83483 MW;  56EACBB9059B9B54 CRC64;
     MSHPYPPGRP GHQAPSRIPD RPRHHARPGA AARARRYVPR PSWAIYAMVF VLLGGILFVE
     AYANGSFIPD YRAENTTGSG QDEVPDEILT GGPIVNTTAD RPQSYRLPAR TVVLTFDDGP
     DERWTPEVMR VLDKHQVPGT FFVLGNQVVR QPDLVRDLVA SGHELGVHTF THPHLTEIPG
     WQRRLEYTQT QLAIAGATGV RTNLLRFPYS SRSDAFVNQD WPLLRQAGEL GYLTVVNDLD
     SRDWERQGPD GMIERTVPPG YSGAITLWHD SGGDRSQTVE ALDRYIPMMK ERGYTFTTVS
     GGLNLALAEA GVSAPVAGPV PATAGERWRG QMLVMAVRAA DFTFVLFGIL FVLVGVLTIG
     RTLLLFVLAL RHARKRRRRD FAWGPPVTAP VSVIVPAYNE KEGIAAAVRS LATGDHPGGI
     EVVVVDDGST DGTADIAAGL GLPNVRVVRK PNGGKPSALN TGVALARHDL IVMVDGDTVF
     EPDAVRRLVQ PFGDPQVGAV AGNVKVGNRR SMIAKWQHIE YVIGFNLDRR LYETLRCMPT
     IPGAIGAFRR EALEYAGGMT DETLAEDTDI TMALGRSGWK VVYEEGARAW TEAPASLGQL
     WKQRYRWSYG TMQAMWKHRR SVLDKGASGR FSRRCLTFLT LFGVLLPLTA PVIDLLALYG
     LIFLDRTETA LAWLAMLGLQ FLTAIVAFRL DREKLGVLWV LPLQQFVYRQ LMYLVLLQSV
     VTALTGGRLG WQKLRRTGLD GVTGTGGRPA GRPATRVGGP
//