ID   A0A137NQJ2_CONC2        Unreviewed;       586 AA.
AC   A0A137NQJ2;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Prolyl endopeptidase {ECO:0000256|RuleBase:RU368024};
DE            EC=3.4.21.- {ECO:0000256|RuleBase:RU368024};
DE   Flags: Fragment;
GN   ORFNames=CONCODRAFT_13536 {ECO:0000313|EMBL:KXN65027.1};
OS   Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638)
OS   (Delacroixia coronata).
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC   Entomophthoromycotina; Entomophthoromycetes; Entomophthorales;
OC   Ancylistaceae; Conidiobolus.
OX   NCBI_TaxID=796925 {ECO:0000313|EMBL:KXN65027.1, ECO:0000313|Proteomes:UP000070444};
RN   [1] {ECO:0000313|EMBL:KXN65027.1, ECO:0000313|Proteomes:UP000070444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 28638 {ECO:0000313|EMBL:KXN65027.1,
RC   ECO:0000313|Proteomes:UP000070444};
RX   PubMed=25977457; DOI=10.1093/gbe/evv090;
RA   Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA   Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA   Spatafora J.W., Berbee M.L.;
RT   "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT   Walls of Algal Ancestors of Land Plants.";
RL   Genome Biol. Evol. 7:1590-1601(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228, ECO:0000256|RuleBase:RU368024}.
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DR   EMBL; KQ965013; KXN65027.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A137NQJ2; -.
DR   EnsemblFungi; KXN65027; KXN65027; CONCODRAFT_13536.
DR   OMA; STWNDVI; -.
DR   OrthoDB; 7264at2759; -.
DR   Proteomes; UP000070444; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 2.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|RuleBase:RU368024, ECO:0000313|EMBL:KXN65027.1};
KW   Protease {ECO:0000256|RuleBase:RU368024};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070444};
KW   Serine protease {ECO:0000256|RuleBase:RU368024}.
FT   DOMAIN          12..101
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          146..298
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          363..562
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KXN65027.1"
SQ   SEQUENCE   586 AA;  66242 MW;  37B2984ACF04D521 CRC64;
     ADQFIISRRY LGGQREAFID PNQLFEKGTT KILNYKISPN GKYLAYVISR KGSDWQSIYV
     VDILYRTQVS EIQWTRYNDE ISWLSDSSGF YYRSYAPANG ITFDQAGLEN EPPKYIGYNL
     HTVKGGRSQE FSITPEAEDN HYGSKARLIE LGQGIASAKD FILSANSDHF IKYLSSDEDG
     MEFITDIGAR NRHIVKVNFN SLDKYEVIVS EFPDKMITDR LFFGSKVVLF SIWDGISFAA
     YIDYRKGSEP IEINMPFGVA SNPRLSGDGS SLAFNLDSFL HYSQSYRFDF DTNTLTLVNT
     FTHPNFDASK FVQYRTLYTA KDGTEIPLLI AHKKGIKPDQ SHPGFLYGYG GFKSIQKPNY
     DQFWAYLLQE KNMVLAIALV RGGSERGYDW WESATKLNKY RSYSDYADAV EFLHKDPKYG
     FVGKNMQFIN GVSNGGLLTA ATCNLIPEKL GGCIADVGVQ DLLRYDRWTV GDGWKEDYGK
     PSDSKEQFNA LMKISPLENV LPAVNATQTK YYPPYLINTA DYDDRVSPVH SLKLAATIQN
     NHKASPHPAL LYVAHHSGHN PSSNTKYLDK CVNAVSLINI ALNKLY
//