UniProt: A0A137NVG1

Database: UniProt
Entry: A0A137NVG1_CONC2

LinkDB:  A0A137NVG1_CONC2 
Original site:  A0A137NVG1_CONC2

All links

Ontology (15)   
   GO (15)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (22)   
   InterPro (13)   
   Pfam (7)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (39)   

Download RDF

ID   A0A137NVG1_CONC2        Unreviewed;      2258 AA.
AC   A0A137NVG1;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   03-MAY-2023, entry version 28.
DE   SubName: Full=Pre-mRNA-processing-splicing factor 8 {ECO:0000313|EMBL:KXN66800.1};
GN   ORFNames=CONCODRAFT_20039 {ECO:0000313|EMBL:KXN66800.1};
OS   Conidiobolus coronatus (strain ATCC 28846 / CBS 209.66 / NRRL 28638)
OS   (Delacroixia coronata).
OC   Eukaryota; Fungi; Fungi incertae sedis; Zoopagomycota;
OC   Entomophthoromycotina; Entomophthoromycetes; Entomophthorales;
OC   Ancylistaceae; Conidiobolus.
OX   NCBI_TaxID=796925 {ECO:0000313|EMBL:KXN66800.1, ECO:0000313|Proteomes:UP000070444};
RN   [1] {ECO:0000313|EMBL:KXN66800.1, ECO:0000313|Proteomes:UP000070444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 28638 {ECO:0000313|EMBL:KXN66800.1,
RC   ECO:0000313|Proteomes:UP000070444};
RX   PubMed=25977457; DOI=10.1093/gbe/evv090;
RA   Chang Y., Wang S., Sekimoto S., Aerts A.L., Choi C., Clum A., LaButti K.M.,
RA   Lindquist E.A., Yee Ngan C., Ohm R.A., Salamov A.A., Grigoriev I.V.,
RA   Spatafora J.W., Berbee M.L.;
RT   "Phylogenomic Analyses Indicate that Early Fungi Evolved Digesting Cell
RT   Walls of Algal Ancestors of Land Plants.";
RL   Genome Biol. Evol. 7:1590-1601(2015).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ964689; KXN66800.1; -; Genomic_DNA.
DR   STRING; 796925.A0A137NVG1; -.
DR   EnsemblFungi; KXN66800; KXN66800; CONCODRAFT_20039.
DR   OMA; ANKWNTS; -.
DR   OrthoDB; 246127at2759; -.
DR   Proteomes; UP000070444; Unassembled WGS sequence.
DR   GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:EnsemblFungi.
DR   GO; GO:0005682; C:U5 snRNP; IEA:EnsemblFungi.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0097157; F:pre-mRNA intronic binding; IEA:EnsemblFungi.
DR   GO; GO:0000386; F:second spliceosomal transesterification activity; IEA:EnsemblFungi.
DR   GO; GO:0030619; F:U1 snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0030620; F:U2 snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0030623; F:U5 snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0017070; F:U6 snRNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000350; P:generation of catalytic spliceosome for second transesterification step; IEA:EnsemblFungi.
DR   GO; GO:0000389; P:mRNA 3'-splice site recognition; IEA:EnsemblFungi.
DR   GO; GO:0000395; P:mRNA 5'-splice site recognition; IEA:EnsemblFungi.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:EnsemblFungi.
DR   CDD; cd08056; MPN_PRP8; 1.
DR   CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR   Gene3D; 1.20.80.40; -; 1.
DR   Gene3D; 3.30.420.230; -; 1.
DR   Gene3D; 3.90.1570.40; -; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR012591; PRO8NT.
DR   InterPro; IPR012592; PROCN.
DR   InterPro; IPR012984; PROCT.
DR   InterPro; IPR027652; PRP8.
DR   InterPro; IPR021983; PRP8_domainIV.
DR   InterPro; IPR043173; Prp8_domainIV_fingers.
DR   InterPro; IPR043172; Prp8_domainIV_palm.
DR   InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR   InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR   InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR   PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF08082; PRO8NT; 1.
DR   Pfam; PF08083; PROCN; 1.
DR   Pfam; PF08084; PROCT; 1.
DR   Pfam; PF12134; PRP8_domainIV; 1.
DR   Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR   Pfam; PF10596; U6-snRNA_bdg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR   PROSITE; PS50249; MPN; 1.
PE   4: Predicted;
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000070444};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT   DOMAIN          2026..2157
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2258 AA;  264050 MW;  BBFAA95562ABE826 CRC64;
     MTDQTLPPQP PGFYPPNSGD LSINHQKLQE KAKRWQQMNA RKYGDNKKMG IAEHQKEAMP
     AEHIRKIIKD HGDMSSKKFR NDKRIYLGAL KYIPHAVLKL LENMPMPWEQ VREVKVLYHI
     TGAITFVNEI PWVVEPIYMA QWGSMWIMMR REKRDRRHFK RMRFPPFDDE EPPLDYGDNI
     LEVEPLDPIQ MEFDEEEDAA IYEWFYDHKP LVDTKFINGP TYKKWNLDTP IMSNLHRLAS
     QLLSDLPDKN YYYLFDINSF ITAKSLNVAI PGGPKFEPLF RDFNPNDDDW NEFNDINKII
     IRQQIRTEYK IAFPYLYNSL PRAVRISHYH HAPVVYIKNE NPDLPVLYYD PIINPIITRT
     FEDTRVMVSH EDELFGDNGD EDDSFTLPEE VDTFLSDTPL YTDNTGNGIQ LYWAPYPFNQ
     KCGNTRRAQD IPLINNWYLE HCPPGQPTKV RVSYQKLLKC YVLNALHRRK PKALNKKYLF
     RQLNATKFFQ FTELDWVEAG LQVCRQGYNM LNLLIHRKNL NYLHLDYNFN LKPVKTLTTK
     ERKKSRFGNA FHLCREILRL TKLIVDAHVQ YRLGNADAYQ LADGLQYMFA HVGQLTGMYK
     FKYKLMRQIR MCKDLKHVIY YRFNTGPVGK GPGVGFWAPG WRVWLFFMRG IVPLLERWLG
     NLLARQFEGR HSKGIAKTVT KQRVESHYDL ELRAAVMHDI TDMMPEGIKA NKSKTILQHL
     SEAWRCWKSN SPWKVPGLPA PVENMILRYV KSKADWWTSV AHYNRERIRR GATVDKTVCK
     KNLGRLTRLW LKAEQERQHN YKKDGPYISS EEGVAIYTST VHWLESRKFS PIPFPPLSYK
     HDTKLLILAL ERLKEAYSIK GRLNQSQREE LGLIEQAYDN PHEALSRIKR LLLTQRAFKE
     VGIEFMDLYS HLIPVYEVEP LEKITDAYLD QYLWYEADKR NLFPNWIKPA DSEPPPQLVY
     KWCQGINNLT DIWVTENGEC NVMLETKLHK PNDFLHFPNE TVETGHPIRL YARYVDKIHI
     FFRFTAEESR DLIQRYLTEH PDPNNENIVG YNNKKCWPRD CRMRLMKHDV NLGRAVFWDI
     KNRLPRSLTT LEWEESFASV YSRDNPNLLF AMSGFDIRIL PKIRNKTEEF TIKDSVWSLV
     NTSTKERTAQ AFLRVDEESM QRFHNRIRQI LMSSGSTTFS KIVNKWNTAL IGLMTYYREA
     VVHTNELLDL LVKCENKIQT RIKIGLNSKM PTRFPPVVFY TPKELGGLGM LSMGHVLIPQ
     SDLRWSKQTE AGITHFRSGM SHDEDQLIPN LYRYLQPWES EFIDSQRVWA EYALKRQEAL
     EQNRRLTLED LEDSWDRGIP RINTLFQKDR HTLAYDKGWR VRTDFKQYQI LKNNPFWWTH
     QRHDGKLWNL NNYRTDMIQA LGGVEGILEH TLFKGTYFPT WEGLFWEKSS GFEESMKFKK
     LTNAQRSGLN QIPNRRFTLW WSPTINRANV YVGFQVQLDL TGIFMHGKIP TLKISLIQIF
     RAHLWQKIHE SLVMDLCQVF DQELEALQIE TVQKETIHPR KSYKMNSSCA DILLFASYKW
     SVSRPSLLTD TKDSMNEATT QKFWIDVQLR WGDFDSHDIE RYTRSRFLTY TTDNMSIYPS
     PCGVMVGVDL AYNLHSAYGN WFPGLKPLAQ QAMNKIMKAN PALYVLRERI RKGLQLYSSE
     PTEPYLSSSN YSELFGNQII WFVDDTNVYR VTIHKTFEGN LTTKPINGAI FIFNPRTGQL
     FLKIIHTSVW AGQKRLSQLA KWKTAEEVAA LIRSLPIEEQ PKQVIVTRKG MLDPLEVHLL
     DFPNIVIKGS ELQLPFQACL KIEKFGDLIL KATEPQMILF NLFDDWLQSI SSYTAFSRLI
     LILRALHINN DKAKLILRPD RNTITEPNHI WPTLTDEQWA KVELQLKDLI LADYGKANNV
     NVASLTQSEI RDIILGMEIS APSIQRQQIA EIEKQATDQS QLTAITTKTH NIHGDEMIVT
     TTSNYETQTF SSKTDWRTRA ISSTNLHLRT NHIYVNSDDI KETGLTYVLP KNILKKFIMI
     SDLRTQIAGF LYGVSPPEHE LVKEIRCIVM VPQHATHQQV HLPHQLPDHD QIKDLEPLGW
     IHTQPNESTQ LSPYDATTHA NIMAENKSWD GEKTVIITCS FTPGSCSLTS YKLTPAGFEW
     GRQNKETGQN PRGYVSSHYE KVQILLSDKF HGFFMTPEES SWNYNFMGAK WNQNMKYTVT
     LDQPKPFYDE SHRPTHFINF AGAEGAPEEG VDREDAFD
//

DBGET integrated database retrieval system